diff --git a/tensorrt_llm/_torch/model_config.py b/tensorrt_llm/_torch/model_config.py
index 27b47acea39..a4ce0092a0b 100644
--- a/tensorrt_llm/_torch/model_config.py
+++ b/tensorrt_llm/_torch/model_config.py
@@ -1,11 +1,14 @@
+import contextlib
 import json
 import os
 from dataclasses import dataclass, field
 from pathlib import Path
 from typing import Dict, Generic, List, Optional, TypeVar
 
+import filelock
 import torch
 import transformers
+from transformers.utils import HF_MODULES_CACHE
 
 from tensorrt_llm import logger
 from tensorrt_llm._torch.pyexecutor.config_utils import is_nemotron_hybrid
@@ -58,6 +61,35 @@ def get_layer_initial_global_assignments(self, layer_idx: int) -> List[int]:
             return None
 
 
+@contextlib.contextmanager
+def config_file_lock(timeout: int = 10):
+    """
+    Context manager for file locking when loading pretrained configs.
+
+    This prevents race conditions when multiple processes try to download/load
+    the same model configuration simultaneously.
+
+    Args:
+        timeout: Maximum time to wait for lock acquisition in seconds
+    """
+    # Use a single global lock file in HF cache directory
+    # This serializes all model loading operations to prevent race conditions
+    lock_path = Path(HF_MODULES_CACHE) / "_remote_code.lock"
+
+    # Create and acquire the lock
+    lock = filelock.FileLock(str(lock_path), timeout=timeout)
+
+    try:
+        with lock:
+            yield
+    except filelock.Timeout:
+        logger.warning(
+            f"Failed to acquire config lock within {timeout} seconds, proceeding without lock"
+        )
+        # Fallback: proceed without locking to avoid blocking indefinitely
+        yield
+
+
 @dataclass(kw_only=True)
 class ModelConfig(Generic[TConfig]):
     pretrained_config: Optional[TConfig] = None
@@ -358,16 +390,20 @@ def from_pretrained(cls,
                         checkpoint_dir: str,
                         trust_remote_code=False,
                         **kwargs):
-        pretrained_config = transformers.AutoConfig.from_pretrained(
-            checkpoint_dir,
-            trust_remote_code=trust_remote_code,
-        )
+        # Use file lock to prevent race conditions when multiple processes
+        # try to import/cache the same remote model config file
+        with config_file_lock():
+            pretrained_config = transformers.AutoConfig.from_pretrained(
+                checkpoint_dir,
+                trust_remote_code=trust_remote_code,
+            )
+
+            # Find the cache path by looking for the config.json file which should be in all
+            # huggingface models
+            model_dir = Path(
+                transformers.utils.hub.cached_file(checkpoint_dir,
+                                                   'config.json')).parent
 
-        # Find the cache path by looking for the config.json file which should be in all
-        # huggingface models
-        model_dir = Path(
-            transformers.utils.hub.cached_file(checkpoint_dir,
-                                               'config.json')).parent
         quant_config = QuantConfig()
         layer_quant_config = None
         moe_backend = kwargs.get('moe_backend', 'CUTLASS')
diff --git a/tests/integration/test_lists/waives.txt b/tests/integration/test_lists/waives.txt
index a4951a2012c..ddbd3eb3e91 100644
--- a/tests/integration/test_lists/waives.txt
+++ b/tests/integration/test_lists/waives.txt
@@ -281,8 +281,6 @@ triton_server/test_triton.py::test_t5_ib[t5-ib] SKIP (https://nvbugs/5456482)
 triton_server/test_triton_llm.py::test_gpt_speculative_decoding_bls[False-False-1---False-True-True-0-128-disableDecoupleMode-inflight_fused_batching-disableTrtOverlap-0.2-guaranteed_no_evict---1-1-1-False-ensemble] SKIP (https://nvbugs/5456485)
 accuracy/test_disaggregated_serving.py::TestLlama3_1_8BInstruct::test_ctx_pp_gen_tp_asymmetric[GSM8K-gen_tp=1-ctx_pp=4] SKIP (https://nvbugs/5434320)
 accuracy/test_llm_api_pytorch.py::TestQwen3_235B_A22B::test_nvfp4[latency_moe_trtllm_eagle3] SKIP (https://nvbugs/5437384)
-accuracy/test_llm_api_pytorch.py::TestDeepSeekR1::test_nvfp4_multi_gpus[latency_trtllmgen] SKIP (https://nvbugs/5445466)
-accuracy/test_llm_api_pytorch.py::TestDeepSeekR1::test_nvfp4_multi_gpus[latency] SKIP (https://nvbugs/5445466)
 llmapi/test_llm_examples.py::test_llmapi_speculative_decoding_mtp SKIP (https://nvbugs/5461796)
 accuracy/test_llm_api.py::TestLlama3_1_8BInstruct::test_gather_generation_logits_cuda_graph SKIP (https://nvbugs/5365525)
 examples/test_phi.py::test_phi_fp8_with_bf16_lora[Phi-3-mini-128k-instruct] SKIP (https://nvbugs/5465143)