diff --git a/CHANGELOG.md b/CHANGELOG.md
index 26a2fa43fd..11cdffb395 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -84,6 +84,8 @@ Other major changes
 
 * Added new modules `Codata.M.Properties` and `Codata.M.Bisimilarity`
 
+* Added new modules `Data.List.Relation.Prefix.Heterogeneous(.Properties)`
+
 * Added new modules `Data.List.First` and `Data.List.First.Properties` for a
   generalization of the notion of "first element in the list to satisfy a
   predicate".
@@ -175,9 +177,10 @@ Other minor additions
   respects : P Respects _≈_ → (All P) Respects _≋_
   ```
 
-* Added new proof to `Data.List.Membership.Propositional.Properties`:
+* Added new proofs to `Data.List.Membership.Propositional.Properties`:
   ```agda
   ∈-allFin : (k : Fin n) → k ∈ allFin n
+  []∈inits : [] ∈ inits as
   ```
 
 * Added new function to `Data.List.Membership.(Setoid/Propositional)`:
@@ -281,6 +284,11 @@ Other minor additions
   wlog : Total _R_ → Symmetric Q → (∀ a b → a R b → Q a b) → ∀ a b → Q a b
   ```
 
+* Added new definition to `Relation.Binary.Core`:
+  ```agda
+  Antisym R S E = ∀ {i j} → R i j → S j i → E i j
+  ```
+
 * Added new proofs to `Relation.Binary.Lattice`:
   ```agda
   Lattice.setoid        : Setoid c ℓ
diff --git a/src/Data/Fin/Subset/Properties.agda b/src/Data/Fin/Subset/Properties.agda
index 476edd9b16..18447e7964 100644
--- a/src/Data/Fin/Subset/Properties.agda
+++ b/src/Data/Fin/Subset/Properties.agda
@@ -133,8 +133,8 @@ x∈⁅y⁆⇔x≡y {_} {x} {y} = equivalence
 ⊆-trans p⊆q q⊆r x∈p = q⊆r (p⊆q x∈p)
 
 ⊆-antisym : ∀ {n} → Antisymmetric _≡_ (_⊆_ {n})
-⊆-antisym {x = []}           {[]}           p⊆q q⊆p = refl
-⊆-antisym {x = x ∷ xs} {y ∷ ys} p⊆q q⊆p with x | y
+⊆-antisym {i = []}     {[]}     p⊆q q⊆p = refl
+⊆-antisym {i = x ∷ xs} {y ∷ ys} p⊆q q⊆p with x | y
 ... | inside  | inside  = cong₂ _∷_ refl (⊆-antisym (drop-∷-⊆ p⊆q) (drop-∷-⊆ q⊆p))
 ... | inside  | outside = contradiction (p⊆q here) λ()
 ... | outside | inside  = contradiction (q⊆p here) λ()
diff --git a/src/Data/List/Base.agda b/src/Data/List/Base.agda
index eb75c3c74c..3f87499cb3 100644
--- a/src/Data/List/Base.agda
+++ b/src/Data/List/Base.agda
@@ -142,7 +142,7 @@ fromMaybe : ∀ {a} {A : Set a} → Maybe A → List A
 fromMaybe (just x) = [ x ]
 fromMaybe nothing  = []
 
-replicate : ∀ {a} {A : Set a} → (n : ℕ) → A → List A
+replicate : ∀ {a} {A : Set a} → ℕ → A → List A
 replicate zero    x = []
 replicate (suc n) x = x ∷ replicate n x
 
diff --git a/src/Data/List/Membership/Propositional/Properties.agda b/src/Data/List/Membership/Propositional/Properties.agda
index 2b26248c6e..2182314171 100644
--- a/src/Data/List/Membership/Propositional/Properties.agda
+++ b/src/Data/List/Membership/Propositional/Properties.agda
@@ -249,6 +249,13 @@ module _ {a} {A : Set a} {_•_ : Op₂ A} where
 ∈-allFin : ∀ {n} (k : Fin n) → k ∈ allFin n
 ∈-allFin = ∈-tabulate⁺
 
+------------------------------------------------------------------------
+-- inits
+
+[]∈inits : ∀ {a} {A : Set a} (as : List A) → [] ∈ inits as
+[]∈inits []       = here refl
+[]∈inits (a ∷ as) = here refl
+
 ------------------------------------------------------------------------
 -- Other properties
 
diff --git a/src/Data/List/Relation/Prefix/Heterogeneous.agda b/src/Data/List/Relation/Prefix/Heterogeneous.agda
new file mode 100644
index 0000000000..dd766d79a7
--- /dev/null
+++ b/src/Data/List/Relation/Prefix/Heterogeneous.agda
@@ -0,0 +1,50 @@
+------------------------------------------------------------------------
+-- The Agda standard library
+--
+-- An inductive definition of the heterogeneous prefix relation
+------------------------------------------------------------------------
+
+module Data.List.Relation.Prefix.Heterogeneous where
+
+open import Level
+open import Data.List.Base as List using (List; []; _∷_)
+open import Data.List.Relation.Pointwise using (Pointwise; []; _∷_)
+open import Data.Product using (∃; _×_; _,_; uncurry)
+open import Relation.Binary using (REL; _⇒_)
+
+module _ {a b r} {A : Set a} {B : Set b} (R : REL A B r) where
+
+  data Prefix : REL (List A) (List B) r where
+    []  : ∀ {bs} → Prefix [] bs
+    _∷_ : ∀ {a b as bs} → R a b → Prefix as bs → Prefix (a ∷ as) (b ∷ bs)
+
+  data PrefixView (as : List A) : List B → Set (b ⊔ r) where
+    _++_ : ∀ {cs} → Pointwise R as cs → ∀ ds → PrefixView as (cs List.++ ds)
+
+module _ {a b r} {A : Set a} {B : Set b} {R : REL A B r} {a b as bs} where
+
+  head : Prefix R (a ∷ as) (b ∷ bs) → R a b
+  head (r ∷ rs) = r
+
+  tail : Prefix R (a ∷ as) (b ∷ bs) → Prefix R as bs
+  tail (r ∷ rs) = rs
+
+  uncons : Prefix R (a ∷ as) (b ∷ bs) → R a b × Prefix R as bs
+  uncons (r ∷ rs) = r , rs
+
+module _ {a b r s} {A : Set a} {B : Set b} {R : REL A B r} {S : REL A B s} where
+
+  map : R ⇒ S → Prefix R ⇒ Prefix S
+  map R⇒S []       = []
+  map R⇒S (r ∷ rs) = R⇒S r ∷ map R⇒S rs
+
+module _ {a b r} {A : Set a} {B : Set b} {R : REL A B r} where
+
+  toView : ∀ {as bs} → Prefix R as bs → PrefixView R as bs
+  toView []       = [] ++ _
+  toView (r ∷ rs) with toView rs
+  ... | rs′ ++ ds = (r ∷ rs′) ++ ds
+
+  fromView : ∀ {as bs} → PrefixView R as bs → Prefix R as bs
+  fromView ([]       ++ ds) = []
+  fromView ((r ∷ rs) ++ ds) = r ∷ fromView (rs ++ ds)
diff --git a/src/Data/List/Relation/Prefix/Heterogeneous/Properties.agda b/src/Data/List/Relation/Prefix/Heterogeneous/Properties.agda
new file mode 100644
index 0000000000..4f57a7d5ad
--- /dev/null
+++ b/src/Data/List/Relation/Prefix/Heterogeneous/Properties.agda
@@ -0,0 +1,221 @@
+------------------------------------------------------------------------
+-- The Agda standard library
+--
+-- Properties of the heterogeneous prefix relation
+------------------------------------------------------------------------
+
+module Data.List.Relation.Prefix.Heterogeneous.Properties where
+
+open import Data.Empty
+open import Data.List.All as All using (All; []; _∷_)
+import Data.List.All.Properties as All
+open import Data.List.Base as List hiding (map; uncons)
+open import Data.List.Membership.Propositional.Properties using ([]∈inits)
+open import Data.List.Relation.Pointwise using (Pointwise; []; _∷_)
+open import Data.List.Relation.Prefix.Heterogeneous as Prefix hiding (PrefixView; _++_)
+open import Data.Nat.Base using (ℕ; zero; suc; _≤_; z≤n; s≤s)
+open import Data.Nat.Properties using (suc-injective)
+open import Data.Product as Prod using (_×_; _,_; proj₁; proj₂; uncurry)
+open import Function
+
+open import Relation.Nullary using (yes; no; ¬_)
+import Relation.Nullary.Decidable as Dec
+open import Relation.Nullary.Product using (_×-dec_)
+open import Relation.Unary as U using (Pred)
+open import Relation.Binary
+open import Relation.Binary.PropositionalEquality as P using (_≡_; _≢_)
+
+------------------------------------------------------------------------
+-- First as a decidable partial order (once made homogeneous)
+
+module _ {a b r} {A : Set a} {B : Set b} {R : REL A B r} where
+
+  fromPointwise : Pointwise R ⇒ Prefix R
+  fromPointwise []       = []
+  fromPointwise (r ∷ rs) = r ∷ fromPointwise rs
+
+  toPointwise : ∀ {as bs} → length as ≡ length bs →
+                Prefix R as bs → Pointwise R as bs
+  toPointwise {bs = []} eq [] = []
+  toPointwise {bs = _ ∷ _} () []
+  toPointwise eq (r ∷ rs) = r ∷ toPointwise (suc-injective eq) rs
+
+module _ {a b c r s t} {A : Set a} {B : Set b} {C : Set c}
+         {R : REL A B r} {S : REL B C s} {T : REL A C t} where
+
+  trans : Trans R S T → Trans (Prefix R) (Prefix S) (Prefix T)
+  trans rs⇒t []       ss       = []
+  trans rs⇒t (r ∷ rs) (s ∷ ss) = rs⇒t r s ∷ trans rs⇒t rs ss
+
+module _ {a b r s e} {A : Set a} {B : Set b}
+         {R : REL A B r} {S : REL B A s} {E : REL A B e} where
+
+  antisym : Antisym R S E → Antisym (Prefix R) (Prefix S) (Pointwise E)
+  antisym rs⇒e []       []       = []
+  antisym rs⇒e (r ∷ rs) (s ∷ ss) = rs⇒e r s ∷ antisym rs⇒e rs ss
+
+------------------------------------------------------------------------
+-- length
+
+module _ {a b r} {A : Set a} {B : Set b} {R : REL A B r} where
+
+  length-mono-Prefix-≤ : ∀ {as bs} → Prefix R as bs → length as ≤ length bs
+  length-mono-Prefix-≤ []       = z≤n
+  length-mono-Prefix-≤ (r ∷ rs) = s≤s (length-mono-Prefix-≤ rs)
+
+------------------------------------------------------------------------
+-- _++_
+
+module _ {a b r} {A : Set a} {B : Set b} {R : REL A B r} where
+
+  ++⁺ : ∀ {as bs cs ds} → Pointwise R as bs →
+        Prefix R cs ds → Prefix R (as ++ cs) (bs ++ ds)
+  ++⁺ []       cs⊆ds = cs⊆ds
+  ++⁺ (r ∷ rs) cs⊆ds = r ∷ (++⁺ rs cs⊆ds)
+
+  ++⁻ : ∀ {as bs cs ds} → length as ≡ length bs →
+        Prefix R (as ++ cs) (bs ++ ds) → Prefix R cs ds
+  ++⁻ {[]}    {[]}    eq rs       = rs
+  ++⁻ {_ ∷ _} {_ ∷ _} eq (_ ∷ rs) = ++⁻ (suc-injective eq) rs
+  ++⁻ {[]} {_ ∷ _} ()
+  ++⁻ {_ ∷ _} {[]} ()
+
+------------------------------------------------------------------------
+-- map
+
+module _ {a b c d r} {A : Set a} {B : Set b} {C : Set c} {D : Set d}
+         {R : REL C D r} where
+
+  map⁺ : ∀ {as bs} (f : A → C) (g : B → D) →
+         Prefix (λ a b → R (f a) (g b)) as bs →
+         Prefix R (List.map f as) (List.map g bs)
+  map⁺ f g []       = []
+  map⁺ f g (r ∷ rs) = r ∷ map⁺ f g rs
+
+  map⁻ : ∀ {as bs} (f : A → C) (g : B → D) →
+         Prefix R (List.map f as) (List.map g bs) →
+         Prefix (λ a b → R (f a) (g b)) as bs
+  map⁻ {[]}     {bs}     f g rs       = []
+  map⁻ {a ∷ as} {[]}     f g ()
+  map⁻ {a ∷ as} {b ∷ bs} f g (r ∷ rs) = r ∷ map⁻ f g rs
+
+------------------------------------------------------------------------
+-- filter
+
+module _ {a b r p q} {A : Set a} {B : Set b} {R : REL A B r}
+         {P : Pred A p} {Q : Pred B q} (P? : U.Decidable P) (Q? : U.Decidable Q)
+         (P⇒Q : ∀ {a b} → R a b → P a → Q b) (Q⇒P : ∀ {a b} → R a b → Q b → P a)
+         where
+
+  filter⁺ : ∀ {as bs} → Prefix R as bs → Prefix R (filter P? as) (filter Q? bs)
+  filter⁺ [] = []
+  filter⁺ {a ∷ as} {b ∷ bs} (r ∷ rs) with P? a | Q? b
+  ... | yes pa | yes qb = r ∷ filter⁺ rs
+  ... | yes pa | no ¬qb = ⊥-elim (¬qb (P⇒Q r pa))
+  ... | no ¬pa | yes qb = ⊥-elim (¬pa (Q⇒P r qb))
+  ... | no ¬pa | no ¬qb = filter⁺ rs
+
+------------------------------------------------------------------------
+-- take
+
+module _ {a b r} {A : Set a} {B : Set b} {R : REL A B r} where
+
+  take⁺ : ∀ {as bs} n → Prefix R as bs → Prefix R (take n as) (take n bs)
+  take⁺ zero    rs       = []
+  take⁺ (suc n) []       = []
+  take⁺ (suc n) (r ∷ rs) = r ∷ take⁺ n rs
+
+  take⁻ : ∀ {as bs} n →
+    Prefix R (take n as) (take n bs) → Prefix R (drop n as) (drop n bs) →
+    Prefix R as bs
+  take⁻                   zero    hds       tls = tls
+  take⁻ {[]}              (suc n) hds       tls = []
+  take⁻ {a ∷ as} {[]}     (suc n) ()        tls
+  take⁻ {a ∷ as} {b ∷ bs} (suc n) (r ∷ hds) tls = r ∷ take⁻ n hds tls
+
+------------------------------------------------------------------------
+-- drop
+
+  drop⁺ : ∀ {as bs} n → Prefix R as bs → Prefix R (drop n as) (drop n bs)
+  drop⁺ zero    rs       = rs
+  drop⁺ (suc n) []       = []
+  drop⁺ (suc n) (r ∷ rs) = drop⁺ n rs
+
+  drop⁻ : ∀ {as bs} n → Pointwise R (take n as) (take n bs) →
+          Prefix R (drop n as) (drop n bs) → Prefix R as bs
+  drop⁻                 zero    hds       tls = tls
+  drop⁻ {[]}            (suc n) hds       tls = []
+  drop⁻ {_ ∷ _} {[]}    (suc n) ()        tls
+  drop⁻ {_ ∷ _} {_ ∷ _} (suc n) (r ∷ hds) tls = r ∷ (drop⁻ n hds tls)
+
+------------------------------------------------------------------------
+-- replicate
+
+  replicate⁺ : ∀ {m n a b} → m ≤ n → R a b → Prefix R (replicate m a) (replicate n b)
+  replicate⁺ z≤n       r = []
+  replicate⁺ (s≤s m≤n) r = r ∷ replicate⁺ m≤n r
+
+  replicate⁻ : ∀ {m n a b} → m ≢ 0 → Prefix R (replicate m a) (replicate n b) → R a b
+  replicate⁻ {zero}  {n}     m≢0 r  = ⊥-elim (m≢0 P.refl)
+  replicate⁻ {suc m} {zero}  m≢0 ()
+  replicate⁻ {suc m} {suc n} m≢0 rs = Prefix.head rs
+
+------------------------------------------------------------------------
+-- inits
+
+module _ {a r} {A : Set a} {R : Rel A r} where
+
+  inits⁺ : ∀ {as} → Pointwise R as as → All (flip (Prefix R) as) (inits as)
+  inits⁺ []       = [] ∷ []
+  inits⁺ (r ∷ rs) = [] ∷ All.map⁺ (All.map (r ∷_) (inits⁺ rs))
+
+  inits⁻ : ∀ {as} → All (flip (Prefix R) as) (inits as) → Pointwise R as as
+  inits⁻ {as = []}     rs       = []
+  inits⁻ {as = a ∷ as} (r ∷ rs) =
+    let (hd , tls) = All.unzip (All.map uncons (All.map⁻ rs)) in
+    All.lookup hd ([]∈inits as) ∷ inits⁻ tls
+
+------------------------------------------------------------------------
+-- zip(With)
+
+module _ {a b c} {A : Set a} {B : Set b} {C : Set c}
+         {d e f} {D : Set d} {E : Set e} {F : Set f}
+         {r s t} {R : REL A D r} {S : REL B E s} {T : REL C F t} where
+
+  zipWith⁺ : ∀ {as bs ds es} {f : A → B → C} {g : D → E → F} →
+    (∀ {a b c d} → R a c → S b d → T (f a b) (g c d)) →
+    Prefix R as ds → Prefix S bs es →
+    Prefix T (zipWith f as bs) (zipWith g ds es)
+  zipWith⁺ f []       ss       = []
+  zipWith⁺ f (r ∷ rs) []       = []
+  zipWith⁺ f (r ∷ rs) (s ∷ ss) = f r s ∷ zipWith⁺ f rs ss
+
+module _ {a b c d} {A : Set a} {B : Set b} {C : Set c} {D : Set d}
+         {r s} {R : REL A C r} {S : REL B D s} where
+
+  private
+    R×S : REL (A × B) (C × D) _
+    R×S (a , b) (c , d) = R a c × S b d
+
+  zip⁺ : ∀ {as bs cs ds} → Prefix R as cs → Prefix S bs ds →
+         Prefix R×S (zip as bs) (zip cs ds)
+  zip⁺ = zipWith⁺ _,_
+
+------------------------------------------------------------------------
+-- Irrelevant
+
+module _ {a b r} {A : Set a} {B : Set b} {R : REL A B r} where
+
+  irrelevant : Irrelevant R → Irrelevant (Prefix R)
+  irrelevant R-irr []       []         = P.refl
+  irrelevant R-irr (r ∷ rs) (r′ ∷ rs′) =
+    P.cong₂ _∷_ (R-irr r r′) (irrelevant R-irr rs rs′)
+
+------------------------------------------------------------------------
+-- Decidability
+
+  prefix? : Decidable R → Decidable (Prefix R)
+  prefix? R? []       bs       = yes []
+  prefix? R? (a ∷ as) []       = no (λ ())
+  prefix? R? (a ∷ as) (b ∷ bs) = Dec.map′ (uncurry _∷_) uncons
+                               $ R? a b ×-dec prefix? R? as bs
diff --git a/src/Relation/Binary/Core.agda b/src/Relation/Binary/Core.agda
index ac6599c2d4..2a51cd7df8 100644
--- a/src/Relation/Binary/Core.agda
+++ b/src/Relation/Binary/Core.agda
@@ -97,8 +97,12 @@ TransFlip P Q R = ∀ {i j k} → Q j k → P i j → R i k
 Transitive : ∀ {a ℓ} {A : Set a} → Rel A ℓ → Set _
 Transitive _∼_ = Trans _∼_ _∼_ _∼_
 
+Antisym : ∀ {a b ℓ₁ ℓ₂ ℓ₃} {A : Set a} {B : Set b} →
+          REL A B ℓ₁ → REL B A ℓ₂ → REL A B ℓ₃ → Set _
+Antisym R S E = ∀ {i j} → R i j → S j i → E i j
+
 Antisymmetric : ∀ {a ℓ₁ ℓ₂} {A : Set a} → Rel A ℓ₁ → Rel A ℓ₂ → Set _
-Antisymmetric _≈_ _≤_ = ∀ {x y} → x ≤ y → y ≤ x → x ≈ y
+Antisymmetric _≈_ _≤_ = Antisym _≤_ _≤_ _≈_
 
 Asymmetric : ∀ {a ℓ} {A : Set a} → Rel A ℓ → Set _
 Asymmetric _<_ = ∀ {x y} → x < y → ¬ (y < x)