diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 7edefac63..f137c3a79 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -3,7 +3,7 @@ on: [push, pull_request]
 jobs:
   build:
     name: >-
-      ${{ matrix.os }} ruby ${{ matrix.ruby }} ${{ matrix.db }}
+      ${{ matrix.os }} ruby ${{ matrix.ruby }} ${{ matrix.db }} ${{ matrix.db-client || '' }}
     # Run all the tests on the new environment as much as possible.
     # https://docs.github.com/en/free-pro-team@latest/actions/reference/specifications-for-github-hosted-runners
     runs-on: ${{ matrix.os }}
@@ -26,6 +26,7 @@ jobs:
           - 2.2
           - 2.1
         db: ['']
+        db-client: [null]
         include:
           # Allow failure due to Mysql2::Error: Unknown system variable 'session_track_system_variables'.
           - {os: ubuntu-16.04, ruby: 2.4, db: mariadb10.0, allow-failure: true}
@@ -36,6 +37,7 @@ jobs:
           - {os: ubuntu-18.04, ruby: 2.4, db: mysql57}
           # Allow failure due to the issue #1165.
           - {os: ubuntu-20.04, ruby: 2.4, db: mysql80, allow-failure: true}
+          - {os: ubuntu-20.04, ruby: 2.4, db: mysql80, db-client: mariadb, allow-failure: true}
           - {os: ubuntu-18.04, ruby: 'head', db: '', allow-failure: true}
           # db: A DB's brew package name in macOS case.
           #     Set a name "db: 'name@X.Y'" when using an old version.
@@ -60,6 +62,10 @@ jobs:
       - run: bundle install --without development
       - if: matrix.db != ''
         run: echo 'DB=${{ matrix.db }}' >> $GITHUB_ENV
+      - if: matrix.db-client != null
+        run: echo 'DB_CLIENT=${{ matrix.db-client }}' >> $GITHUB_ENV
       - run: sudo echo "127.0.0.1 mysql2gem.example.com" | sudo tee -a /etc/hosts
       - run: bash ci/setup.sh
+      - run: bundle exec rake compile
+      - run: ldd lib/mysql2/mysql2.so
       - run: bundle exec rake
diff --git a/ci/mysql80.sh b/ci/mysql80.sh
index b4921b1f8..a29ed60e8 100644
--- a/ci/mysql80.sh
+++ b/ci/mysql80.sh
@@ -10,4 +10,4 @@ apt-key add support/5072E1F5.asc
 wget -q --spider http://repo.mysql.com/apt/ubuntu/dists/$(lsb_release -cs)/mysql-8.0
 add-apt-repository 'http://repo.mysql.com/apt/ubuntu mysql-8.0'
 apt-get update -qq
-apt-get install -qq mysql-server libmysqlclient-dev
+apt-get install -qq mysql-server
diff --git a/ci/setup.sh b/ci/setup.sh
index 97e89818a..32f185241 100644
--- a/ci/setup.sh
+++ b/ci/setup.sh
@@ -9,6 +9,8 @@ CHANGED_PASSWORD=false
 # https://stackoverflow.com/questions/56052177/
 CHANGED_PASSWORD_BY_RECREATE=false
 
+echo "DB: ${DB-}, DB_CLIENT: ${DB_CLIENT-}"
+
 # Install the default used DB if DB is not set.
 if [[ -n ${GITHUB_ACTIONS-} && -z ${DB-} ]]; then
   if command -v lsb_release > /dev/null; then
@@ -41,6 +43,12 @@ fi
 # Install MySQL 8.0 if DB=mysql80
 if [[ -n ${DB-} && x$DB =~ ^xmysql80 ]]; then
   sudo bash ci/mysql80.sh
+  if [[ -n ${DB_CLIENT-} && x$DB_CLIENT =~ ^xmariadb ]]; then
+    sudo apt-get install -qq libmariadb-dev-compat
+  else
+    sudo apt-get install -qq libmysqlclient-dev
+  fi
+
   CHANGED_PASSWORD=true
 fi