diff --git a/asgiref/sync.py b/asgiref/sync.py
index 54496efe..ffe6047f 100644
--- a/asgiref/sync.py
+++ b/asgiref/sync.py
@@ -231,7 +231,7 @@ async def new_loop_wrap() -> None:
                 finally:
                     del self.loop_thread_executors[loop]
 
-            if self.main_event_loop is not None:
+            if self.main_event_loop is not None and self.main_event_loop.is_running():
                 try:
                     self.main_event_loop.call_soon_threadsafe(
                         self.main_event_loop.create_task, awaitable