diff --git a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Common/SerializationTest.cs b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Common/SerializationTest.cs
index d893fca6899bf1..9028aa53ae05a2 100644
--- a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Common/SerializationTest.cs
+++ b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Common/SerializationTest.cs
@@ -8,6 +8,7 @@
 
 namespace System.Resources.Extensions.Tests.Common;
 
+[ConditionalClass(typeof(PlatformDetection), nameof(PlatformDetection.IsBinaryFormatterSupported))]
 public abstract class SerializationTest<TSerializer> where TSerializer : ISerializer
 {
     public static TheoryData<FormatterTypeStyle, FormatterAssemblyStyle> FormatterOptions => new()
diff --git a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Common/SystemDrawingTests.cs b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Common/SystemDrawingTests.cs
index 81b491e887edba..9fcb7d60a6cc89 100644
--- a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Common/SystemDrawingTests.cs
+++ b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Common/SystemDrawingTests.cs
@@ -7,10 +7,11 @@
 
 namespace System.Resources.Extensions.Tests.Common;
 
-[ConditionalClass(typeof(PlatformDetection), nameof(PlatformDetection.IsDrawingSupported))]
+// This type can not be annotated with [ConditionalClass(typeof(PlatformDetection), nameof(PlatformDetection.IsDrawingSupported))]
+// because the base type is annotated with [ConditionalClass(typeof(PlatformDetection), nameof(PlatformDetection.IsBinaryFormatterSupported))]
 public abstract class SystemDrawingTests<T> : SerializationTest<T> where T : ISerializer
 {
-    [Theory]
+    [ConditionalTheory(typeof(PlatformDetection), nameof(PlatformDetection.IsDrawingSupported), nameof(PlatformDetection.SupportsComInterop))]
     [MemberData(nameof(FormatterOptions))]
     [SupportedOSPlatform("windows")]
     public void Bitmap_RoundTrip(FormatterTypeStyle typeStyle, FormatterAssemblyStyle assemblyMatching)
@@ -20,7 +21,7 @@ public void Bitmap_RoundTrip(FormatterTypeStyle typeStyle, FormatterAssemblyStyl
         deserialized.Size.Should().Be(bitmap.Size);
     }
 
-    [Theory]
+    [ConditionalTheory(typeof(PlatformDetection), nameof(PlatformDetection.IsDrawingSupported), nameof(PlatformDetection.SupportsComInterop))]
     [MemberData(nameof(FormatterOptions))]
     [SupportedOSPlatform("windows")]
     public void Png_RoundTrip(FormatterTypeStyle typeStyle, FormatterAssemblyStyle assemblyMatching)
diff --git a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/FormattedObject/BinaryFormattedTypes.cs b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/FormattedObject/BinaryFormattedTypes.cs
index b49320a1cadf5b..f9641ce9c86613 100644
--- a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/FormattedObject/BinaryFormattedTypes.cs
+++ b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/FormattedObject/BinaryFormattedTypes.cs
@@ -8,6 +8,7 @@
 
 namespace System.Resources.Extensions.Tests.FormattedObject;
 
+[ConditionalClass(typeof(PlatformDetection), nameof(PlatformDetection.IsBinaryFormatterSupported))]
 public class BinaryFormattedTypes
 {
     [Theory]
diff --git a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/FormattedObject/SystemDrawingTests.cs b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/FormattedObject/SystemDrawingTests.cs
index bb26d521a9e3e7..99a95fbb6c70da 100644
--- a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/FormattedObject/SystemDrawingTests.cs
+++ b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/FormattedObject/SystemDrawingTests.cs
@@ -9,7 +9,7 @@ namespace System.Resources.Extensions.Tests.FormattedObject;
 
 public class SystemDrawingTests : Common.SystemDrawingTests<FormattedObjectSerializer>
 {
-    [Fact]
+    [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsDrawingSupported))]
     public void PointF_Parse()
     {
         PointF input = new() { X = 123.5f, Y = 456.1f };
@@ -26,7 +26,7 @@ public void PointF_Parse()
         classInfo.GetSingle("y").Should().Be(input.Y);
     }
 
-    [Fact]
+    [ConditionalFact(typeof(PlatformDetection), nameof(PlatformDetection.IsDrawingSupported))]
     public void RectangleF_Parse()
     {
         RectangleF input = new(x: 123.5f, y: 456.1f, width: 100.25f, height: 200.75f);
diff --git a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Legacy/BinaryFormatterTests.cs b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Legacy/BinaryFormatterTests.cs
index d8492e19dd574a..8f99d4437ba36b 100644
--- a/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Legacy/BinaryFormatterTests.cs
+++ b/src/libraries/System.Resources.Extensions/tests/BinaryFormatTests/Legacy/BinaryFormatterTests.cs
@@ -15,6 +15,7 @@
 
 namespace BinaryFormatTests.FormatterTests;
 
+[ConditionalClass(typeof(PlatformDetection), nameof(PlatformDetection.IsBinaryFormatterSupported))]
 public partial class BinaryFormatterTests
 {
     [Theory]
diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index 754ba0940ab820..9e4ac5317716fe 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -425,6 +425,11 @@
     <ProjectExclusions Remove="$(MSBuildThisFileDirectory)System.Collections\tests\System.Collections.Tests.csproj" />
     <ProjectExclusions Remove="$(MSBuildThisFileDirectory)System.IO.IsolatedStorage\tests\System.IO.IsolatedStorage.Tests.csproj" />
   </ItemGroup>
+  
+  <ItemGroup Condition="'$(TestNativeAot)' == 'true' or '$(TargetsMobile)' == 'true'">
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Resources.Extensions\tests\BinaryFormatTests\System.Resources.Extensions.BinaryFormat.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Resources.Extensions\tests\CompatTests\System.Resources.Extensions.Compat.Tests.csproj" />
+  </ItemGroup>
 
   <ItemGroup Condition="'$(TestNativeAot)' == 'true' and '$(RunDisabledNativeAotTests)' != 'true'">
     <!-- https://github.com/dotnet/runtime/issues/72908 -->
@@ -506,8 +511,6 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Mail\tests\Functional\System.Net.Mail.Functional.Tests.csproj"
                       Condition="'$(TargetOS)' == 'windows'"/>
 
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Resources.Extensions\tests\CompatTests\System.Resources.Extensions.Compat.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Resources.Extensions\tests\BinaryFormatTests\System.Resources.Extensions.BinaryFormat.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.VisualBasic.Core\tests\Microsoft.VisualBasic.Core.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.CodeDom\tests\System.CodeDom.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.ComponentModel.Annotations\tests\System.ComponentModel.Annotations.Tests.csproj" />