diff --git a/eng/common/performance/performance-setup.sh b/eng/common/performance/performance-setup.sh
index 7321feb5c7e689..2fd148fec2fdf1 100755
--- a/eng/common/performance/performance-setup.sh
+++ b/eng/common/performance/performance-setup.sh
@@ -88,6 +88,10 @@ while (($# > 0)); do
       internal=true
       shift 1
       ;;
+    --alpine)
+      alpine=true
+      shift 1
+      ;;
     --llvm)
       llvm=true
       shift 1
@@ -143,6 +147,7 @@ while (($# > 0)); do
       echo "  --monodotnet                   Pass the path to the mono dotnet for mono performance testing."
       echo "  --wasm                         Path to the unpacked wasm runtime pack."
       echo "  --latestdotnet                 --dotnet-versions will not be specified. --dotnet-versions defaults to LKG version in global.json "
+      echo "  --alpine                       Set for runs on Alpine"
       echo ""
       exit 0
       ;;
@@ -198,12 +203,20 @@ if [[ "$internal" == true ]]; then
     else
         queue=Ubuntu.1804.Amd64.Tiger.Perf
     fi
+
+    if [[ "$alpine" = "true" ]]; then
+        queue=alpine.amd64.tiger.perf
+    fi
 else
     if [[ "$architecture" = "arm64" ]]; then
         queue=ubuntu.1804.armarch.open
     else
         queue=Ubuntu.1804.Amd64.Open
     fi
+
+    if [[ "$alpine" = "true" ]]; then
+        queue=alpine.amd64.tiger.perf
+    fi
 fi
 
 if [[ "$mono_dotnet" != "" ]] && [[ "$monointerpreter" == "false" ]]; then
diff --git a/eng/pipelines/coreclr/perf.yml b/eng/pipelines/coreclr/perf.yml
index 9cee03fed01e20..09ba7b0d44dbd1 100644
--- a/eng/pipelines/coreclr/perf.yml
+++ b/eng/pipelines/coreclr/perf.yml
@@ -19,6 +19,9 @@ trigger:
     - SECURITY.md
     - THIRD-PARTY-NOTICES.TXT
 
+variables:
+  - template: /eng/pipelines/common/variables.yml
+
 jobs:
 
 # build coreclr and libraries
@@ -31,6 +34,7 @@ jobs:
     - windows_x64
     - windows_x86
     - Linux_arm64
+    - Linux_musl_x64
     jobParameters:
       testGroup: perf
 
@@ -126,6 +130,7 @@ jobs:
     - windows_x64
     - windows_x86
     - Linux_arm64
+    - Linux_musl_x64
     jobParameters:
       testGroup: perf
       liveLibrariesBuildConfig: Release
diff --git a/eng/pipelines/coreclr/templates/perf-job.yml b/eng/pipelines/coreclr/templates/perf-job.yml
index 74a3015ed15d8c..6d97afc4358699 100644
--- a/eng/pipelines/coreclr/templates/perf-job.yml
+++ b/eng/pipelines/coreclr/templates/perf-job.yml
@@ -39,6 +39,7 @@ jobs:
     projectFile: ${{ parameters.projectFile }}
     runKind: ${{ parameters.runKind }}
     additionalSetupParameters: ${{ parameters.additionalSetupParameters }}
+    container: ${{ parameters.container }}
     # Test job depends on the corresponding build job
     dependsOn:
     - ${{ format('coreclr_{0}_product_build_{1}{2}_{3}_{4}', parameters.runtimeVariant, parameters.osGroup, parameters.osSubgroup, parameters.archType, parameters.buildConfig) }}
@@ -59,8 +60,10 @@ jobs:
         extraSetupParameters: --architecture ${{ parameters.archType }} --monodotnet $(Build.SourcesDirectory)/.dotnet-mono
       ${{ if eq(parameters.runtimeType, 'wasm') }}:
         extraSetupParameters: --architecture ${{ parameters.archType }} --wasm $(librariesDownloadDir)/bin/wasm
-      ${{ if eq(parameters.runtimeType, 'coreclr') }}:
+      ${{ if and(eq(parameters.runtimeType, 'coreclr'), ne(parameters.osSubGroup, '_musl')) }}:
         extraSetupParameters: --corerootdirectory $(Build.SourcesDirectory)/artifacts/tests/coreclr/${{ parameters.osGroup }}.${{ parameters.archType }}.Release/Tests/Core_Root --architecture ${{ parameters.archType }}
+      ${{ if and(eq(parameters.runtimeType, 'coreclr'), eq(parameters.osSubGroup, '_musl')) }}:
+        extraSetupParameters: --corerootdirectory $(Build.SourcesDirectory)/artifacts/tests/coreclr/${{ parameters.osGroup }}.${{ parameters.archType }}.Release/Tests/Core_Root --architecture ${{ parameters.archType }} --alpine
     
     variables: ${{ parameters.variables }}
 
diff --git a/eng/pipelines/coreclr/templates/run-performance-job.yml b/eng/pipelines/coreclr/templates/run-performance-job.yml
index 3517eabedfe16e..395eae47d1f950 100644
--- a/eng/pipelines/coreclr/templates/run-performance-job.yml
+++ b/eng/pipelines/coreclr/templates/run-performance-job.yml
@@ -52,8 +52,9 @@ jobs:
 
     - IsInternal: ''
     - HelixApiAccessToken: ''
-    - HelixPreCommandStemWindows: 'py -3 -m venv %HELIX_WORKITEM_PAYLOAD%\.venv;call %HELIX_WORKITEM_PAYLOAD%\.venv\Scripts\activate.bat;set PYTHONPATH=;py -3 -m pip install --user azure.storage.blob==12.0.0 --force-reinstall;py -3 -m pip install --user azure.storage.queue==12.0.0 --force-reinstall;set "PERFLAB_UPLOAD_TOKEN=$(PerfCommandUploadToken)"'
-    - HelixPreCommandStemLinux: 'sudo apt-get -y install python3-venv;python3 -m venv $HELIX_WORKITEM_PAYLOAD/.venv;source $HELIX_WORKITEM_PAYLOAD/.venv/Scripts/activate;export PYTHONPATH=;pip3 install --user azure.storage.blob==12.0.0 --force-reinstall;pip3 install --user azure.storage.queue==12.0.0 --force-reinstall;sudo apt-get update;sudo apt -y install curl dirmngr apt-transport-https lsb-release ca-certificates;curl -sL https://deb.nodesource.com/setup_12.x | sudo -E bash -;sudo apt-get -y install nodejs;sudo apt-get -y install npm;npm install --prefix $HELIX_WORKITEM_PAYLOAD jsvu -g;$HELIX_WORKITEM_PAYLOAD/bin/jsvu --os=linux64 --engines=v8;export PERFLAB_UPLOAD_TOKEN="$(PerfCommandUploadTokenLinux)"'
+    - HelixPreCommandStemWindows: 'py -m pip install -U pip;py -3 -m venv %HELIX_WORKITEM_PAYLOAD%\.venv;call %HELIX_WORKITEM_PAYLOAD%\.venv\Scripts\activate.bat;set PYTHONPATH=;py -3 -m pip install --user azure.storage.blob==12.0.0;py -3 -m pip install --user azure.storage.queue==12.0.0;set "PERFLAB_UPLOAD_TOKEN=$(PerfCommandUploadToken)"'
+    - HelixPreCommandStemLinux: 'python3 -m pip install -U pip;sudo apt-get -y install python3-venv;python3 -m venv $HELIX_WORKITEM_PAYLOAD/.venv;source $HELIX_WORKITEM_PAYLOAD/.venv/Scripts/activate;export PYTHONPATH=;pip3 install --user azure.storage.blob==12.0.0;pip3 install --user azure.storage.queue==12.0.0;sudo apt-get update;sudo apt -y install curl dirmngr apt-transport-https lsb-release ca-certificates;curl -sL https://deb.nodesource.com/setup_12.x | sudo -E bash -;sudo apt-get -y install nodejs;sudo apt-get -y install npm;npm install --prefix $HELIX_WORKITEM_PAYLOAD jsvu -g;$HELIX_WORKITEM_PAYLOAD/bin/jsvu --os=linux64 --engines=v8;export PERFLAB_UPLOAD_TOKEN="$(PerfCommandUploadTokenLinux)"'
+    - HelixPreCommandStemMsul: 'sudo apk add icu-libs krb5-libs libgcc libintl libssl1.1 libstdc++ zlib;sudo apk add cargo --repository http://sjc.edge.kernel.org/alpine/edge/community ;sudo apk add libgdiplus --repository http://dl-cdn.alpinelinux.org/alpine/edge/testing; python3 -m venv $HELIX_WORKITEM_PAYLOAD/.venv;source $HELIX_WORKITEM_PAYLOAD/.venv/bin/activate;export PYTHONPATH=;python3 -m pip install -U pip;pip3 install azure.storage.blob==12.7.1;pip3 install azure.storage.queue==12.1.5;export PERFLAB_UPLOAD_TOKEN="$(PerfCommandUploadTokenLinux)"'
     - ExtraMSBuildLogsWindows: 'set MSBUILDDEBUGCOMM=1;set "MSBUILDDEBUGPATH=%HELIX_WORKITEM_UPLOAD_ROOT%"'
     - ExtraMSBuildLogsLinux: 'export MSBUILDDEBUGCOMM=1;export "MSBUILDDEBUGPATH=$HELIX_WORKITEM_UPLOAD_ROOT"'
     - HelixPreCommand: ''
@@ -64,8 +65,12 @@ jobs:
         - HelixPreCommand: $(HelixPreCommandStemWindows);$(ExtraMSBuildLogsWindows)
         - IsInternal: -Internal
       - ${{ if ne(parameters.osGroup, 'windows') }}:
-        - HelixPreCommand: $(HelixPreCommandStemLinux);$(ExtraMSBuildLogsLinux)
-        - IsInternal: --internal
+        - ${{ if eq(parameters.osSubGroup, '_musl') }}:
+          - HelixPreCommand: $(HelixPreCommandStemMsul);$(ExtraMSBuildLogsLinux)
+          - IsInternal: --internal
+        - ${{ if ne(parameters.osSubGroup, '_musl') }}:
+          - HelixPreCommand: $(HelixPreCommandStemLinux);$(ExtraMSBuildLogsLinux)
+          - IsInternal: --internal
       - group: DotNet-HelixApi-Access
       - group: dotnet-benchview
 
diff --git a/eng/pipelines/coreclr/templates/run-scenarios-job.yml b/eng/pipelines/coreclr/templates/run-scenarios-job.yml
index de22968e287b5e..7eda89088ee2d8 100644
--- a/eng/pipelines/coreclr/templates/run-scenarios-job.yml
+++ b/eng/pipelines/coreclr/templates/run-scenarios-job.yml
@@ -65,9 +65,12 @@ jobs:
       - ${{ if eq(parameters.osGroup, 'windows') }}:
         - AdditionalHelixPreCommands: 'py -3 -m venv %HELIX_WORKITEM_PAYLOAD%\.venv;call %HELIX_WORKITEM_PAYLOAD%\.venv\Scripts\activate.bat;set PYTHONPATH=;py -3 -m pip install --user azure.storage.blob==12.0.0 --force-reinstall;py -3 -m pip install --user azure.storage.queue==12.0.0 --force-reinstall;set "PERFLAB_UPLOAD_TOKEN=$(PerfCommandUploadToken)"'
         - IsInternal: -Internal      
-      - ${{ if ne(parameters.osGroup, 'windows') }}:
+      - ${{ if and(ne(parameters.osGroup, 'windows'), ne(parameters.osSubGroup, '_musl')) }}:
         - AdditionalHelixPreCommands: 'sudo apt-get -y install python3-venv;python3 -m venv $HELIX_WORKITEM_PAYLOAD/.venv;source $HELIX_WORKITEM_PAYLOAD/.venv/Scripts/activate;export PYTHONPATH=;pip3 install --user azure.storage.blob==12.0.0 --force-reinstall;pip3 install --user azure.storage.queue==12.0.0 --force-reinstall;export PERFLAB_UPLOAD_TOKEN="$(PerfCommandUploadTokenLinux)"'
         - IsInternal: --internal
+      - ${{ if and(ne(parameters.osGroup, 'windows'), eq(parameters.osSubGroup, '_musl')) }}:
+        - AdditionalHelixPreCommands: 'sudo apk add py3-virtualenv;python3 -m venv $HELIX_WORKITEM_PAYLOAD/.venv;source $HELIX_WORKITEM_PAYLOAD/.venv/Scripts/activate;export PYTHONPATH=;pip3 install --user azure.storage.blob==12.0.0 --force-reinstall;pip3 install --user azure.storage.queue==12.0.0 --force-reinstall;export PERFLAB_UPLOAD_TOKEN="$(PerfCommandUploadTokenLinux)"'
+        - IsInternal: --internal
       - group: DotNet-HelixApi-Access
       - group: dotnet-benchview