diff --git a/eng/Versions.props b/eng/Versions.props
index 9d07766ec31049..f7b0120ea4c73c 100644
--- a/eng/Versions.props
+++ b/eng/Versions.props
@@ -181,7 +181,7 @@
     <!-- ICU -->
     <MicrosoftNETCoreRuntimeICUTransportVersion>7.0.0-rc.2.22458.3</MicrosoftNETCoreRuntimeICUTransportVersion>
     <!-- MsQuic -->
-    <MicrosoftNativeQuicMsQuicVersion>2.1</MicrosoftNativeQuicMsQuicVersion>
+    <MicrosoftNativeQuicMsQuicVersion>2.1.1</MicrosoftNativeQuicMsQuicVersion>
     <SystemNetMsQuicTransportVersion>7.0.0-alpha.1.22406.1</SystemNetMsQuicTransportVersion>
     <!-- Mono LLVM -->
     <runtimelinuxarm64MicrosoftNETCoreRuntimeMonoLLVMSdkVersion>11.1.0-alpha.1.22459.1</runtimelinuxarm64MicrosoftNETCoreRuntimeMonoLLVMSdkVersion>
diff --git a/eng/pipelines/libraries/helix-queues-setup.yml b/eng/pipelines/libraries/helix-queues-setup.yml
index cac632e79177b1..ca02a670d2142c 100644
--- a/eng/pipelines/libraries/helix-queues-setup.yml
+++ b/eng/pipelines/libraries/helix-queues-setup.yml
@@ -39,9 +39,9 @@ jobs:
     # Linux arm64
     - ${{ if eq(parameters.platform, 'Linux_arm64') }}:
       - ${{ if or(eq(parameters.jobParameters.isExtraPlatforms, true), eq(parameters.jobParameters.includeAllPlatforms, true)) }}:
-        - (Ubuntu.2204.Arm64.Open)Ubuntu.1804.ArmArch.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:ubuntu-22.04-helix-arm64v8-20220504035342-1b9461f
+        - (Ubuntu.2204.Arm64.Open)Ubuntu.1804.ArmArch.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:ubuntu-22.04-helix-arm64v8-20220909180915-6c91216
       - ${{ if or(ne(parameters.jobParameters.isExtraPlatforms, true), eq(parameters.jobParameters.includeAllPlatforms, true)) }}:
-        - (Ubuntu.1804.ArmArch.Open)Ubuntu.1804.ArmArch.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:ubuntu-18.04-helix-arm64v8-20220427172132-97d8652
+        - (Ubuntu.1804.Arm64.Open)Ubuntu.1804.ArmArch.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:ubuntu-18.04-helix-arm64v8-20220909180906-777c06f
 
     # Linux musl x64
     - ${{ if eq(parameters.platform, 'Linux_musl_x64') }}:
@@ -62,26 +62,26 @@ jobs:
           - (Centos.8.Amd64.Open)Ubuntu.2204.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:centos-8-helix-20201229003624-c1bf759
           - RedHat.7.Amd64.Open
           - SLES.15.Amd64.Open
-          - (Fedora.34.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:fedora-34-helix-20220809205730-e7e8d1c
-          - (Ubuntu.2204.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:ubuntu-22.04-helix-amd64-20220504035722-1b9461f
-          - (Debian.10.Amd64.Open)Ubuntu.2204.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:debian-10-helix-amd64-20220810215022-f344011
+          - (Fedora.34.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:fedora-34-helix-20220908220224-98605e8
+          - (Ubuntu.2204.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:ubuntu-22.04-helix-amd64-20220909180913-1b9461f
+          - (Debian.10.Amd64.Open)Ubuntu.2204.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:debian-10-helix-amd64-20220912172935-59ee6b3
         - ${{ if or(ne(parameters.jobParameters.testScope, 'outerloop'), ne(parameters.jobParameters.runtimeFlavor, 'mono')) }}:
           - ${{ if or(eq(parameters.jobParameters.isExtraPlatforms, true), eq(parameters.jobParameters.includeAllPlatforms, true)) }}:
             - (Centos.8.Amd64.Open)Ubuntu.1604.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:centos-8-helix-20201229003624-c1bf759
             - SLES.15.Amd64.Open
-            - (Fedora.34.Amd64.Open)ubuntu.1804.amd64.open@mcr.microsoft.com/dotnet-buildtools/prereqs:fedora-34-helix-20220809205730-e7e8d1c
+            - (Fedora.34.Amd64.Open)ubuntu.1804.amd64.open@mcr.microsoft.com/dotnet-buildtools/prereqs:fedora-34-helix-20220908220224-98605e8
             - Ubuntu.2204.Amd64.Open
-            - (Debian.11.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:debian-11-helix-amd64-20220810215032-f344011
+            - (Debian.11.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:debian-11-helix-amd64-20220908132354-59ee6b3
             - (Mariner.1.0.Amd64.Open)ubuntu.1604.amd64.open@mcr.microsoft.com/dotnet-buildtools/prereqs:cbl-mariner-1.0-helix-20210528192219-92bf620
-            - (openSUSE.15.2.Amd64.Open)ubuntu.1604.amd64.open@mcr.microsoft.com/dotnet-buildtools/prereqs:opensuse-15.2-helix-amd64-20211018152525-9cc02fe
+            - (openSUSE.15.2.Amd64.Open)ubuntu.1604.amd64.open@mcr.microsoft.com/dotnet-buildtools/prereqs:opensuse-15.2-helix-amd64-20220912173041-1d2766c
           - ${{ if or(ne(parameters.jobParameters.isExtraPlatforms, true), eq(parameters.jobParameters.includeAllPlatforms, true)) }}:
             - (Centos.7.Amd64.Open)Ubuntu.1604.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:centos-7-mlnet-helix-20220601183719-dde38af
             - RedHat.7.Amd64.Open
-            - (Debian.10.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:debian-10-helix-amd64-20220810215022-f344011
+            - (Debian.10.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:debian-10-helix-amd64-20220912172935-59ee6b3
             - Ubuntu.1804.Amd64.Open
       - ${{ if or(eq(parameters.jobParameters.interpreter, 'true'), eq(parameters.jobParameters.isSingleFile, true)) }}:
         # Limiting interp runs as we don't need as much coverage.
-        - (Debian.10.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:debian-10-helix-amd64-20210304164434-56c6673
+        - (Debian.10.Amd64.Open)Ubuntu.1804.Amd64.Open@mcr.microsoft.com/dotnet-buildtools/prereqs:debian-10-helix-amd64-20220912172935-59ee6b3
 
     # Linux s390x
     - ${{ if eq(parameters.platform, 'Linux_s390x') }}:
diff --git a/src/libraries/System.Net.Quic/src/System.Net.Quic.csproj b/src/libraries/System.Net.Quic/src/System.Net.Quic.csproj
index a19e8592056f62..257af8dbb8808b 100644
--- a/src/libraries/System.Net.Quic/src/System.Net.Quic.csproj
+++ b/src/libraries/System.Net.Quic/src/System.Net.Quic.csproj
@@ -11,6 +11,7 @@
     <DefineConstants Condition="'$(TargetPlatformIdentifier)' == 'windows'">$(DefineConstants);TARGET_WINDOWS</DefineConstants>
     <GeneratePlatformNotSupportedAssemblyMessage Condition="'$(TargetPlatformIdentifier)' == ''">SR.SystemNetQuic_PlatformNotSupported</GeneratePlatformNotSupportedAssemblyMessage>
     <ApiExclusionListPath Condition="'$(TargetPlatformIdentifier)' == ''">ExcludeApiList.PNSE.txt</ApiExclusionListPath>
+    <UseQuicTransportPackage  Condition="'$(UseQuicTransportPackage)' == ''">false</UseQuicTransportPackage>
   </PropertyGroup>
   <ItemGroup>
     <AssemblyAttribute Include="System.Runtime.Versioning.RequiresPreviewFeaturesAttribute" />
@@ -137,17 +138,15 @@
     <Reference Include="System.Diagnostics.StackTrace" Condition="'$(Configuration)' == 'Debug'" />
   </ItemGroup>
 
-  <!-- Support for deploying msquic -->
-  <ItemGroup Condition="'$(TargetPlatformIdentifier)' == 'windows' and
-                        ('$(TargetArchitecture)' == 'x64' or '$(TargetArchitecture)' == 'x86') and '$(DotNetBuildFromSource)' != 'true'">
+  <!-- Support for deploying msquic on Windows -->
+  <ItemGroup Condition="'$(TargetPlatformIdentifier)' == 'windows' and '$(UseQuicTransportPackage)' == 'true' and '$(DotNetBuildFromSource)' != 'true'">
     <BinPlaceDir Include="$(MicrosoftNetCoreAppRuntimePackNativeDir)" ItemName="NativeBinPlaceItem" />
     <BinPlaceDir Include="$(NetCoreAppCurrentTestHostSharedFrameworkPath)" ItemName="NativeBinPlaceItem" />
     <BinPlaceDir Include="$(LibrariesAllBinArtifactsPath)" ItemName="NativeBinPlaceItem" />
     <BinPlaceDir Include="$(LibrariesNativeArtifactsPath)" ItemName="NativeBinPlaceItem" />
     <NativeBinPlaceItem Include="$(PkgSystem_Net_MsQuic_Transport)\runtimes\win10-$(TargetArchitecture)\native\*" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetPlatformIdentifier)' == 'windows' and
-                        ('$(TargetArchitecture)' == 'arm64' or '$(TargetArchitecture)' == 'arm') and '$(DotNetBuildFromSource)' != 'true'">
+  <ItemGroup Condition="'$(TargetPlatformIdentifier)' == 'windows' and '$(UseQuicTransportPackage)' != 'true' and '$(DotNetBuildFromSource)' != 'true'">
     <BinPlaceDir Include="$(MicrosoftNetCoreAppRuntimePackNativeDir)" ItemName="NativeBinPlaceItem" />
     <BinPlaceDir Include="$(NetCoreAppCurrentTestHostSharedFrameworkPath)" ItemName="NativeBinPlaceItem" />
     <BinPlaceDir Include="$(LibrariesAllBinArtifactsPath)" ItemName="NativeBinPlaceItem" />