diff --git a/packages/react-reconciler/src/ReactFiberScheduler.js b/packages/react-reconciler/src/ReactFiberScheduler.js
index 390f46af4ea4c..5cde36aa99e14 100644
--- a/packages/react-reconciler/src/ReactFiberScheduler.js
+++ b/packages/react-reconciler/src/ReactFiberScheduler.js
@@ -181,6 +181,7 @@ const {ReactCurrentDispatcher, ReactCurrentOwner} = ReactSharedInternals;
 
 let didWarnAboutStateTransition;
 let didWarnSetStateChildContext;
+let suppressUpdateOnUnmountedWarning;
 let warnAboutUpdateOnUnmounted;
 let warnAboutInvalidUpdates;
 
@@ -199,6 +200,7 @@ if (enableSchedulerTracing) {
 if (__DEV__) {
   didWarnAboutStateTransition = false;
   didWarnSetStateChildContext = false;
+  suppressUpdateOnUnmountedWarning = false;
   const didWarnStateUpdateForUnmountedComponent = {};
 
   warnAboutUpdateOnUnmounted = function(fiber: Fiber, isClass: boolean) {
@@ -605,6 +607,12 @@ function flushPassiveEffects() {
     // We call the scheduled callback instead of commitPassiveEffects directly
     // to ensure tracing works correctly.
     passiveEffectCallback();
+    if (__DEV__) {
+      // Flushing passive effects could have led to unmounting a component
+      // that the user has already called setState on. So temporarily suppress
+      // any warnings about that until the next scheduleWork call.
+      suppressUpdateOnUnmountedWarning = true;
+    }
   }
 }
 
@@ -1847,18 +1855,27 @@ export function warnIfNotCurrentlyBatchingInDev(fiber: Fiber): void {
 
 function scheduleWork(fiber: Fiber, expirationTime: ExpirationTime) {
   const root = scheduleWorkToRoot(fiber, expirationTime);
+
+  let suppressWarning;
+  if (__DEV__) {
+    suppressWarning = suppressUpdateOnUnmountedWarning;
+    suppressUpdateOnUnmountedWarning = false;
+  }
+
   if (root === null) {
     if (__DEV__) {
-      switch (fiber.tag) {
-        case ClassComponent:
-          warnAboutUpdateOnUnmounted(fiber, true);
-          break;
-        case FunctionComponent:
-        case ForwardRef:
-        case MemoComponent:
-        case SimpleMemoComponent:
-          warnAboutUpdateOnUnmounted(fiber, false);
-          break;
+      if (!suppressWarning) {
+        switch (fiber.tag) {
+          case ClassComponent:
+            warnAboutUpdateOnUnmounted(fiber, true);
+            break;
+          case FunctionComponent:
+          case ForwardRef:
+          case MemoComponent:
+          case SimpleMemoComponent:
+            warnAboutUpdateOnUnmounted(fiber, false);
+            break;
+        }
       }
     }
     return;
diff --git a/packages/react-reconciler/src/__tests__/ReactHooks-test.internal.js b/packages/react-reconciler/src/__tests__/ReactHooks-test.internal.js
index 087c8572cd66e..e2b62b0922762 100644
--- a/packages/react-reconciler/src/__tests__/ReactHooks-test.internal.js
+++ b/packages/react-reconciler/src/__tests__/ReactHooks-test.internal.js
@@ -1699,6 +1699,74 @@ describe('ReactHooks', () => {
     ).toThrow('Hello');
   });
 
+  it('does not fire a false positive warning when previous effect unmounts the component', () => {
+    let {useState, useEffect} = React;
+    let globalListener;
+    let _setState;
+
+    function A() {
+      const [show, setShow] = useState(true);
+      function hideMe() {
+        setShow(false);
+      }
+      return show ? <B hideMe={hideMe} /> : null;
+    }
+
+    function B(props) {
+      return <C {...props} />;
+    }
+
+    function C({hideMe}) {
+      const [, setState] = useState();
+
+      useEffect(() => {
+        let isStale = false;
+
+        _setState = setState;
+        globalListener = () => {
+          if (!isStale) {
+            setState('hello');
+          }
+          if (!isStale) {
+            setState('goodbye');
+          }
+          if (!isStale) {
+            setState('hello');
+          }
+        };
+
+        return () => {
+          isStale = true;
+          hideMe();
+        };
+      });
+      return null;
+    }
+
+    ReactTestRenderer.act(() => {
+      ReactTestRenderer.create(<A />);
+    });
+
+    expect(() => {
+      globalListener();
+      globalListener();
+    }).toWarnDev([
+      'An update to C inside a test was not wrapped in act',
+      'An update to C inside a test was not wrapped in act',
+      // Note: should *not* warn about updates on unmounted component.
+      // Because there's no way for component to know it got unmounted.
+    ]);
+
+    // Verify the warning isn't disabled permanently.
+    expect(() => {
+      ReactTestRenderer.act(() => {
+        _setState('bad');
+      });
+    }).toWarnDev([
+      "Can't perform a React state update on an unmounted component",
+    ]);
+  });
+
   // Regression test for https://github.com/facebook/react/issues/14790
   it('does not fire a false positive warning when suspending memo', async () => {
     const {Suspense, useState} = React;