diff --git a/sentry_sdk/integrations/django/__init__.py b/sentry_sdk/integrations/django/__init__.py
index 03d0545b1d..c82ef4f148 100644
--- a/sentry_sdk/integrations/django/__init__.py
+++ b/sentry_sdk/integrations/django/__init__.py
@@ -1,6 +1,7 @@
 # -*- coding: utf-8 -*-
 from __future__ import absolute_import
 
+import inspect
 import sys
 import threading
 import weakref
@@ -665,12 +666,21 @@ def _set_db_data(span, cursor_or_db):
     vendor = db.vendor
     span.set_data(SPANDATA.DB_SYSTEM, vendor)
 
-    connection_params = (
-        cursor_or_db.connection.get_dsn_parameters()
-        if hasattr(cursor_or_db, "connection")
+    if (
+        hasattr(cursor_or_db, "connection")
         and hasattr(cursor_or_db.connection, "get_dsn_parameters")
-        else db.get_connection_params()
-    )
+        and inspect.isfunction(cursor_or_db.connection.get_dsn_parameters)
+    ):
+        # Some custom backends override `__getattr__`, making it look like `cursor_or_db`
+        # actually has a `connection` and the `connection` has a `get_dsn_parameters`
+        # attribute, only to throw an error once you actually want to call it.
+        # Hence the `inspect` check whether `get_dsn_parameters` is an actual callable
+        # function.
+        connection_params = cursor_or_db.connection.get_dsn_parameters()
+
+    else:
+        connection_params = db.get_connection_params()
+
     db_name = connection_params.get("dbname") or connection_params.get("database")
     if db_name is not None:
         span.set_data(SPANDATA.DB_NAME, db_name)
diff --git a/tests/integrations/django/test_basic.py b/tests/integrations/django/test_basic.py
index 379c4d9614..e599c78843 100644
--- a/tests/integrations/django/test_basic.py
+++ b/tests/integrations/django/test_basic.py
@@ -22,10 +22,11 @@
 from sentry_sdk._compat import PY2, PY310
 from sentry_sdk import capture_message, capture_exception, configure_scope
 from sentry_sdk.consts import SPANDATA
-from sentry_sdk.integrations.django import DjangoIntegration
+from sentry_sdk.integrations.django import DjangoIntegration, _set_db_data
 from sentry_sdk.integrations.django.signals_handlers import _get_receiver_name
 from sentry_sdk.integrations.django.caching import _get_span_description
 from sentry_sdk.integrations.executing import ExecutingIntegration
+from sentry_sdk.tracing import Span
 from tests.integrations.django.myapp.wsgi import application
 from tests.integrations.django.utils import pytest_mark_django_db_decorator
 
@@ -656,6 +657,24 @@ def test_db_connection_span_data(sentry_init, client, capture_events):
             assert data.get(SPANDATA.SERVER_PORT) == "5432"
 
 
+def test_set_db_data_custom_backend():
+    class DummyBackend(object):
+        # https://github.com/mongodb/mongo-python-driver/blob/6ffae5522c960252b8c9adfe2a19b29ff28187cb/pymongo/collection.py#L126
+        def __getattr__(self, attr):
+            return self
+
+        def __call__(self):
+            raise TypeError
+
+        def get_connection_params(self):
+            return {}
+
+    try:
+        _set_db_data(Span(), DummyBackend())
+    except TypeError:
+        pytest.fail("A TypeError was raised")
+
+
 @pytest.mark.parametrize(
     "transaction_style,client_url,expected_transaction,expected_source,expected_response",
     [