diff --git a/sentry_sdk/utils.py b/sentry_sdk/utils.py
index 595bbe0cf3..3b0ab8d746 100644
--- a/sentry_sdk/utils.py
+++ b/sentry_sdk/utils.py
@@ -591,9 +591,14 @@ def serialize_frame(
     if tb_lineno is None:
         tb_lineno = frame.f_lineno
 
+    try:
+        os_abs_path = os.path.abspath(abs_path) if abs_path else None
+    except Exception:
+        os_abs_path = None
+
     rv = {
         "filename": filename_for_module(module, abs_path) or None,
-        "abs_path": os.path.abspath(abs_path) if abs_path else None,
+        "abs_path": os_abs_path,
         "function": function or "<unknown>",
         "module": module,
         "lineno": tb_lineno,