diff --git a/llvm/lib/CodeGen/AsmPrinter/PseudoProbePrinter.cpp b/llvm/lib/CodeGen/AsmPrinter/PseudoProbePrinter.cpp
index 618deef2a74ea..4bf3bdfb5adfd 100644
--- a/llvm/lib/CodeGen/AsmPrinter/PseudoProbePrinter.cpp
+++ b/llvm/lib/CodeGen/AsmPrinter/PseudoProbePrinter.cpp
@@ -18,6 +18,11 @@
 #include "llvm/MC/MCPseudoProbe.h"
 #include "llvm/MC/MCStreamer.h"
 
+#ifndef NDEBUG
+#include "llvm/IR/Module.h"
+#include "llvm/Support/WithColor.h"
+#endif
+
 using namespace llvm;
 
 void PseudoProbeHandler::emitPseudoProbe(uint64_t Guid, uint64_t Index,
@@ -35,6 +40,9 @@ void PseudoProbeHandler::emitPseudoProbe(uint64_t Guid, uint64_t Index,
     uint64_t &CallerGuid = NameGuidMap[Name];
     if (!CallerGuid)
       CallerGuid = Function::getGUIDAssumingExternalLinkage(Name);
+#ifndef NDEBUG
+    verifyGuidExistenceInDesc(CallerGuid, Name);
+#endif
     uint64_t CallerProbeId = PseudoProbeDwarfDiscriminator::extractProbeIndex(
         InlinedAt->getDiscriminator());
     ReversedInlineStack.emplace_back(CallerGuid, CallerProbeId);
@@ -51,4 +59,28 @@ void PseudoProbeHandler::emitPseudoProbe(uint64_t Guid, uint64_t Index,
   SmallVector<InlineSite, 8> InlineStack(llvm::reverse(ReversedInlineStack));
   Asm->OutStreamer->emitPseudoProbe(Guid, Index, Type, Attr, Discriminator,
                                     InlineStack, Asm->CurrentFnSym);
+#ifndef NDEBUG
+  verifyGuidExistenceInDesc(
+      Guid, DebugLoc ? DebugLoc->getSubprogramLinkageName() : "");
+#endif
+}
+
+#ifndef NDEBUG
+void PseudoProbeHandler::verifyGuidExistenceInDesc(uint64_t Guid,
+                                                   StringRef FuncName) {
+  NamedMDNode *Desc = Asm->MF->getFunction().getParent()->getNamedMetadata(
+      PseudoProbeDescMetadataName);
+  assert(Desc && "pseudo probe does not exist");
+
+  // Keep DescGuidSet up to date.
+  for (size_t I = DescGuidSet.size(), E = Desc->getNumOperands(); I != E; ++I) {
+    const auto *MD = cast<MDNode>(Desc->getOperand(I));
+    auto *ID = mdconst::extract<ConstantInt>(MD->getOperand(0));
+    DescGuidSet.insert(ID->getZExtValue());
+  }
+
+  if (!DescGuidSet.contains(Guid))
+    WithColor::warning() << "Guid:" << Guid << " Name:" << FuncName
+                         << " does not exist in pseudo probe desc\n";
 }
+#endif
diff --git a/llvm/lib/CodeGen/AsmPrinter/PseudoProbePrinter.h b/llvm/lib/CodeGen/AsmPrinter/PseudoProbePrinter.h
index f11b552387501..e950b23bb4280 100644
--- a/llvm/lib/CodeGen/AsmPrinter/PseudoProbePrinter.h
+++ b/llvm/lib/CodeGen/AsmPrinter/PseudoProbePrinter.h
@@ -15,6 +15,10 @@
 
 #include "llvm/ADT/DenseMap.h"
 
+#ifndef NDEBUG
+#include "llvm/ADT/DenseSet.h"
+#endif
+
 namespace llvm {
 
 class AsmPrinter;
@@ -26,6 +30,13 @@ class PseudoProbeHandler {
   // Name to GUID map, used as caching/memoization for speed.
   DenseMap<StringRef, uint64_t> NameGuidMap;
 
+#ifndef NDEBUG
+  // All GUID in llvm.pseudo_probe_desc.
+  DenseSet<uint64_t> DescGuidSet;
+
+  void verifyGuidExistenceInDesc(uint64_t Guid, StringRef FuncName);
+#endif
+
 public:
   PseudoProbeHandler(AsmPrinter *A) : Asm(A) {};
 
diff --git a/llvm/test/CodeGen/X86/pseudo-probe-desc-check.ll b/llvm/test/CodeGen/X86/pseudo-probe-desc-check.ll
new file mode 100644
index 0000000000000..0b1d16d33b5f0
--- /dev/null
+++ b/llvm/test/CodeGen/X86/pseudo-probe-desc-check.ll
@@ -0,0 +1,46 @@
+; RUN: llc -mtriple=x86_64-unknown-linux-gnu < %s 2>&1 | FileCheck %s
+; RUN: llc -mtriple=x86_64-unknown-windows-msvc < %s 2>&1 | FileCheck %s
+
+; CHECK: warning: Guid:8314849053352128226 Name:inlinee does not exist in pseudo probe desc
+; CHECK: warning: Guid:6492337042787843907 Name:extract2 does not exist in pseudo probe desc
+
+target datalayout = "e-m:e-p270:32:32-p271:32:32-p272:64:64-i64:64-i128:128-f80:128-n8:16:32:64-S128"
+
+define void @extract1() !dbg !8 {
+entry:
+  call void @llvm.pseudoprobe(i64 6028998432455395745, i64 1, i32 0, i64 -1), !dbg !11
+  call void @llvm.pseudoprobe(i64 8314849053352128226, i64 1, i32 0, i64 -1), !dbg !12
+  ret void, !dbg !16
+}
+
+define void @extract2() !dbg !17 {
+entry:
+  call void @llvm.pseudoprobe(i64 6492337042787843907, i64 1, i32 0, i64 -1), !dbg !18
+  ret void, !dbg !18
+}
+
+declare void @llvm.pseudoprobe(i64, i64, i32, i64)
+
+!llvm.dbg.cu = !{!0}
+!llvm.module.flags = !{!2, !3, !4, !5, !6}
+!llvm.pseudo_probe_desc = !{!7}
+
+!0 = distinct !DICompileUnit(language: DW_LANG_C11, file: !1, producer: "clang", isOptimized: false, emissionKind: LineTablesOnly, splitDebugInlining: false, nameTableKind: None)
+!1 = !DIFile(filename: "test.c", directory: "/home/foo")
+!2 = !{i32 7, !"Dwarf Version", i32 4}
+!3 = !{i32 2, !"Debug Info Version", i32 3}
+!4 = !{i32 1, !"wchar_size", i32 4}
+!5 = !{i32 7, !"uwtable", i32 2}
+!6 = !{i32 7, !"frame-pointer", i32 2}
+!7 = !{i64 6028998432455395745, i64 281479271677951, !"extract1"}
+!8 = distinct !DISubprogram(name: "extract1", scope: !1, file: !1, line: 4, type: !9, scopeLine: 4, spFlags: DISPFlagDefinition, unit: !0)
+!9 = !DISubroutineType(types: !10)
+!10 = !{}
+!11 = !DILocation(line: 5, column: 3, scope: !8)
+!12 = !DILocation(line: 2, column: 1, scope: !13, inlinedAt: !14)
+!13 = distinct !DISubprogram(name: "inlinee", scope: !1, file: !1, line: 1, type: !9, scopeLine: 1, spFlags: DISPFlagDefinition, unit: !0)
+!14 = distinct !DILocation(line: 5, column: 3, scope: !15)
+!15 = !DILexicalBlockFile(scope: !8, file: !1, discriminator: 455082007)
+!16 = !DILocation(line: 6, column: 1, scope: !8)
+!17 = distinct !DISubprogram(name: "extract2", scope: !1, file: !1, line: 8, type: !9, scopeLine: 8, spFlags: DISPFlagDefinition, unit: !0)
+!18 = !DILocation(line: 9, column: 1, scope: !17)