diff --git a/doc/source/whatsnew/v1.5.3.rst b/doc/source/whatsnew/v1.5.3.rst
index d65446604a83f..e7428956c50b5 100644
--- a/doc/source/whatsnew/v1.5.3.rst
+++ b/doc/source/whatsnew/v1.5.3.rst
@@ -15,6 +15,7 @@ Fixed regressions
 ~~~~~~~~~~~~~~~~~
 - Fixed performance regression in :meth:`Series.isin` when ``values`` is empty (:issue:`49839`)
 - Fixed regression in :meth:`DataFrameGroupBy.transform` when used with ``as_index=False`` (:issue:`49834`)
+- Enforced reversion of ``color`` as an alias for ``c`` and ``size`` as an alias for ``s`` in function :meth:`DataFrame.plot.scatter` (:issue:`49732`)
 -
 
 .. ---------------------------------------------------------------------------
diff --git a/pandas/plotting/_core.py b/pandas/plotting/_core.py
index 529849e740169..aef1eb5d59e68 100644
--- a/pandas/plotting/_core.py
+++ b/pandas/plotting/_core.py
@@ -1681,19 +1681,7 @@ def scatter(self, x, y, s=None, c=None, **kwargs) -> PlotAccessor:
             ...                       c='species',
             ...                       colormap='viridis')
         """
-        size = kwargs.pop("size", None)
-        if s is not None and size is not None:
-            raise TypeError("Specify exactly one of `s` and `size`")
-        if s is not None or size is not None:
-            kwargs["s"] = s if s is not None else size
-
-        color = kwargs.pop("color", None)
-        if c is not None and color is not None:
-            raise TypeError("Specify exactly one of `c` and `color`")
-        if c is not None or color is not None:
-            kwargs["c"] = c if c is not None else color
-
-        return self(kind="scatter", x=x, y=y, **kwargs)
+        return self(kind="scatter", x=x, y=y, s=s, c=c, **kwargs)
 
     def hexbin(
         self, x, y, C=None, reduce_C_function=None, gridsize=None, **kwargs