diff --git a/AUTHORS b/AUTHORS
index e9e033c73f0..ff41614954e 100644
--- a/AUTHORS
+++ b/AUTHORS
@@ -14,6 +14,7 @@ Ahn Ki-Wook
 Akhilesh Ramakrishnan
 Akiomi Kamakura
 Alan Velasco
+Aleksandr Brodin
 Alessio Izzo
 Alex Jones
 Alex Lambson
diff --git a/changelog/4112.feature.rst b/changelog/4112.feature.rst
new file mode 100644
index 00000000000..5ce12d38e8f
--- /dev/null
+++ b/changelog/4112.feature.rst
@@ -0,0 +1 @@
+Support use `pytest.mark.usefixtures` with `pytest.mark.parametrize`.
diff --git a/src/_pytest/compat.py b/src/_pytest/compat.py
index 73d77f978f7..118e7b72b6b 100644
--- a/src/_pytest/compat.py
+++ b/src/_pytest/compat.py
@@ -163,6 +163,7 @@ def getfuncargnames(
         and not isinstance(
             inspect.getattr_static(cls, name, default=None), staticmethod
         )
+        and not hasattr(function, "__self__")
     ):
         arg_names = arg_names[1:]
     # Remove any names that will be replaced with mocks.
diff --git a/src/_pytest/python.py b/src/_pytest/python.py
index cbb82e39090..02300a0aa64 100644
--- a/src/_pytest/python.py
+++ b/src/_pytest/python.py
@@ -1799,9 +1799,13 @@ def __init__(
         if keywords:
             self.keywords.update(keywords)
 
+        fm = self.session._fixturemanager
+        fixtureinfo_ = fm.getfixtureinfo(self, self.obj, self.cls)
         if fixtureinfo is None:
-            fm = self.session._fixturemanager
-            fixtureinfo = fm.getfixtureinfo(self, self.obj, self.cls)
+            fixtureinfo = fixtureinfo_
+        elif set(fixtureinfo_.names_closure) != set(fixtureinfo.names_closure):
+            fixtureinfo_.name2fixturedefs.update(fixtureinfo.name2fixturedefs)
+            fixtureinfo = fixtureinfo_
         self._fixtureinfo: FuncFixtureInfo = fixtureinfo
         self.fixturenames = fixtureinfo.names_closure
         self._initrequest()
diff --git a/testing/python/metafunc.py b/testing/python/metafunc.py
index 4ee9e32d6e9..fa9f445368a 100644
--- a/testing/python/metafunc.py
+++ b/testing/python/metafunc.py
@@ -2112,3 +2112,31 @@ def test_converted_to_str(a, b):
                 "*= 6 passed in *",
             ]
         )
+
+    def test_simple_usefixtures_single_argname(self, pytester: Pytester) -> None:
+        pytester.makepyfile(
+            """
+            import pytest
+
+            @pytest.fixture
+            def some_fixture():
+                pytest.skip()
+
+            @pytest.mark.parametrize("val", [
+                1,
+                pytest.param(2, marks=pytest.mark.usefixtures('some_fixture')),
+                3,
+            ])
+            def test_foo(request, val):
+                assert val
+        """
+        )
+        result = pytester.runpytest("-vv", "-s")
+        result.assert_outcomes(passed=2, skipped=1)
+        result.stdout.fnmatch_lines(
+            [
+                "test_simple_usefixtures_single_argname.py::test_foo[1] PASSED",
+                "test_simple_usefixtures_single_argname.py::test_foo[2] SKIPPED",
+                "test_simple_usefixtures_single_argname.py::test_foo[3] PASSED",
+            ]
+        )