diff --git a/src/_pytest/pytester.py b/src/_pytest/pytester.py
index a050dad09e5..1d8ae798820 100644
--- a/src/_pytest/pytester.py
+++ b/src/_pytest/pytester.py
@@ -915,6 +915,10 @@ def parseconfig(self, *args):
 
         import _pytest.config
 
+        capman = self.request.config.pluginmanager.getplugin("capturemanager")
+        if capman and not capman.is_capturing():
+            args = ["-p", "no:capture"] + args
+
         config = _pytest.config._prepareconfig(args, self.plugins)
         # we don't know what the test will do with this half-setup config
         # object and thus we make sure it gets unconfigured properly in any
diff --git a/testing/test_pdb.py b/testing/test_pdb.py
index 3c56f40e1cb..b8af4198ae0 100644
--- a/testing/test_pdb.py
+++ b/testing/test_pdb.py
@@ -1217,3 +1217,22 @@ def set_trace(self, *args):
     result.stdout.fnmatch_lines(
         ["*set_trace_called*", "*set_trace_called*", "* 1 passed in *"]
     )
+
+
+def test_capture_with_testdir_parseconfig(testdir):
+    """Test capturing with inner node of config setup.  Also tests #4330."""
+    p = testdir.makepyfile(
+        """
+        def test_inner(testdir):
+            hello = testdir.makefile(".py", hello="world")
+            __import__('pdb').set_trace()
+            node = testdir.parseconfig(hello)
+    """
+    )
+    child = testdir.spawn_pytest("-s -p pytester %s" % p)
+    child.expect(r"\(Pdb")
+    child.sendline("n")
+    child.sendline("c")
+    rest = child.read().decode("utf8")
+    TestPDB.flush(child)
+    assert child.exitstatus == 0, rest