diff --git a/Misc/NEWS.d/next/Core and Builtins/2023-02-21-23-42-39.gh-issue-102027.fQARG0.rst b/Misc/NEWS.d/next/Core and Builtins/2023-02-21-23-42-39.gh-issue-102027.fQARG0.rst
new file mode 100644
index 00000000000000..42d96b54677e41
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2023-02-21-23-42-39.gh-issue-102027.fQARG0.rst	
@@ -0,0 +1,2 @@
+Fix SSE2 and SSE3 detection in ``_blake2`` internal module. Patch by Max
+Bachmann.
diff --git a/Modules/_blake2/impl/blake2-config.h b/Modules/_blake2/impl/blake2-config.h
index f5dd6faa9e6867..c09cb4bcf06723 100644
--- a/Modules/_blake2/impl/blake2-config.h
+++ b/Modules/_blake2/impl/blake2-config.h
@@ -53,7 +53,7 @@
 #endif
 #endif
 
-#ifdef HAVE_SSE41
+#ifdef HAVE_SSE4_1
 #ifndef HAVE_SSSE3
 #define HAVE_SSSE3
 #endif