diff --git a/Lib/ctypes/test/test_structures.py b/Lib/ctypes/test/test_structures.py
index f57bb2b5c178c0..c4fc6092c45ef2 100644
--- a/Lib/ctypes/test/test_structures.py
+++ b/Lib/ctypes/test/test_structures.py
@@ -1,4 +1,6 @@
 import platform
+from platform import architecture as _architecture
+import struct
 import sys
 import unittest
 from ctypes.test import need_symbol
@@ -7,6 +9,7 @@
                     c_uint8, c_uint16, c_uint32,
                     c_short, c_ushort, c_int, c_uint,
                     c_long, c_ulong, c_longlong, c_ulonglong, c_float, c_double)
+from ctypes.util import find_library
 from struct import calcsize
 import _ctypes_test
 from test import support
@@ -479,6 +482,66 @@ class X(Structure):
         self.assertEqual(s.first, got.first)
         self.assertEqual(s.second, got.second)
 
+    def _test_issue18060(self, Vector):
+        # The call to atan2() should succeed if the
+        # class fields were correctly cloned in the
+        # subclasses. Otherwise, it will segfault.
+        if sys.platform == 'win32':
+            libm = CDLL(find_library('msvcrt.dll'))
+        else:
+            libm = CDLL(find_library('m'))
+
+        libm.atan2.argtypes = [Vector]
+        libm.atan2.restype = c_double
+
+        arg = Vector(y=0.0, x=-1.0)
+        self.assertAlmostEqual(libm.atan2(arg), 3.141592653589793)
+
+    @unittest.skipIf(_architecture() == ('64bit', 'WindowsPE'), "can't test Windows x64 build")
+    @unittest.skipUnless(sys.byteorder == 'little', "can't test on this platform")
+    def test_issue18060_a(self):
+        # This test case calls
+        # PyCStructUnionType_update_stgdict() for each
+        # _fields_ assignment, and PyCStgDict_clone()
+        # for the Mid and Vector class definitions.
+        class Base(Structure):
+            _fields_ = [('y', c_double),
+                        ('x', c_double)]
+        class Mid(Base):
+            pass
+        Mid._fields_ = []
+        class Vector(Mid): pass
+        self._test_issue18060(Vector)
+
+    @unittest.skipIf(_architecture() == ('64bit', 'WindowsPE'), "can't test Windows x64 build")
+    @unittest.skipUnless(sys.byteorder == 'little', "can't test on this platform")
+    def test_issue18060_b(self):
+        # This test case calls
+        # PyCStructUnionType_update_stgdict() for each
+        # _fields_ assignment.
+        class Base(Structure):
+            _fields_ = [('y', c_double),
+                        ('x', c_double)]
+        class Mid(Base):
+            _fields_ = []
+        class Vector(Mid):
+            _fields_ = []
+        self._test_issue18060(Vector)
+
+    @unittest.skipIf(_architecture() == ('64bit', 'WindowsPE'), "can't test Windows x64 build")
+    @unittest.skipUnless(sys.byteorder == 'little', "can't test on this platform")
+    def test_issue18060_c(self):
+        # This test case calls
+        # PyCStructUnionType_update_stgdict() for each
+        # _fields_ assignment.
+        class Base(Structure):
+            _fields_ = [('y', c_double)]
+        class Mid(Base):
+            _fields_ = []
+        class Vector(Mid):
+            _fields_ = [('x', c_double)]
+        self._test_issue18060(Vector)
+
     def test_array_in_struct(self):
         # See bpo-22273
 
diff --git a/Misc/NEWS.d/next/Library/2019-05-17-07-22-33.bpo-18060.5mqTQM.rst b/Misc/NEWS.d/next/Library/2019-05-17-07-22-33.bpo-18060.5mqTQM.rst
new file mode 100644
index 00000000000000..3fefbc3efb63c0
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2019-05-17-07-22-33.bpo-18060.5mqTQM.rst
@@ -0,0 +1,2 @@
+Fixed a class inheritance issue that can cause segfaults when deriving two or more levels of subclasses from a base class of Structure or Union.
+
diff --git a/Modules/_ctypes/_ctypes.c b/Modules/_ctypes/_ctypes.c
index fc73264ff5a32c..50cad3075b2fb4 100644
--- a/Modules/_ctypes/_ctypes.c
+++ b/Modules/_ctypes/_ctypes.c
@@ -4387,10 +4387,10 @@ _init_pos_args(PyObject *self, PyTypeObject *type,
         return index;
     }
 
-    for (i = 0;
-         i < dict->length && (i+index) < PyTuple_GET_SIZE(args);
+    for (i = index;
+         i < dict->length && i < PyTuple_GET_SIZE(args);
          ++i) {
-        PyObject *pair = PySequence_GetItem(fields, i);
+        PyObject *pair = PySequence_GetItem(fields, i - index);
         PyObject *name, *val;
         int res;
         if (!pair)
@@ -4400,7 +4400,7 @@ _init_pos_args(PyObject *self, PyTypeObject *type,
             Py_DECREF(pair);
             return -1;
         }
-        val = PyTuple_GET_ITEM(args, i + index);
+        val = PyTuple_GET_ITEM(args, i);
         if (kwds) {
             res = PyDict_Contains(kwds, name);
             if (res != 0) {
@@ -4421,7 +4421,7 @@ _init_pos_args(PyObject *self, PyTypeObject *type,
         if (res == -1)
             return -1;
     }
-    return index + dict->length;
+    return dict->length;
 }
 
 static int
diff --git a/Modules/_ctypes/stgdict.c b/Modules/_ctypes/stgdict.c
index 7746f95692f346..cbd705d492219e 100644
--- a/Modules/_ctypes/stgdict.c
+++ b/Modules/_ctypes/stgdict.c
@@ -660,7 +660,7 @@ PyCStructUnionType_update_stgdict(PyObject *type, PyObject *fields, int isStruct
 
     stgdict->size = size;
     stgdict->align = total_align;
-    stgdict->length = len;      /* ADD ffi_ofs? */
+    stgdict->length = ffi_ofs + len;
 
 /*
  * On Arm platforms, structs with at most 4 elements of any floating point