diff --git a/mypy/checker.py b/mypy/checker.py
index 4cd5c6c5580d..2c71c468ed46 100644
--- a/mypy/checker.py
+++ b/mypy/checker.py
@@ -5325,9 +5325,11 @@ def conditional_type_map(expr: Expression,
                 return None, {}
             else:
                 # we can only restrict when the type is precise, not bounded
-                proposed_precise_type = UnionType([type_range.item
-                                          for type_range in proposed_type_ranges
-                                          if not type_range.is_upper_bound])
+                proposed_precise_type = UnionType.make_union([
+                    type_range.item
+                    for type_range in proposed_type_ranges
+                    if not type_range.is_upper_bound
+                ])
                 remaining_type = restrict_subtype_away(current_type, proposed_precise_type)
                 return {expr: proposed_type}, {expr: remaining_type}
         else:
diff --git a/mypy/subtypes.py b/mypy/subtypes.py
index 52d03282494f..b1f6dba58cef 100644
--- a/mypy/subtypes.py
+++ b/mypy/subtypes.py
@@ -1131,6 +1131,8 @@ def restrict_subtype_away(t: Type, s: Type, *, ignore_promotions: bool = False)
                      if (isinstance(get_proper_type(item), AnyType) or
                          not covers_at_runtime(item, s, ignore_promotions))]
         return UnionType.make_union(new_items)
+    elif covers_at_runtime(t, s, ignore_promotions):
+        return UninhabitedType()
     else:
         return t
 
diff --git a/test-data/unit/check-inference.test b/test-data/unit/check-inference.test
index 80bc40b6ca98..652a26163858 100644
--- a/test-data/unit/check-inference.test
+++ b/test-data/unit/check-inference.test
@@ -1975,7 +1975,7 @@ T = TypeVar('T')
 
 class A:
     def f(self) -> None:
-        self.g() # E: Too few arguments for "g" of "A"   
+        self.g() # E: Too few arguments for "g" of "A"
         self.g(1)
     @dec
     def g(self, x: str) -> None: pass
diff --git a/test-data/unit/check-narrowing.test b/test-data/unit/check-narrowing.test
index 8cf85536f3b9..6b030ae49a86 100644
--- a/test-data/unit/check-narrowing.test
+++ b/test-data/unit/check-narrowing.test
@@ -1143,3 +1143,32 @@ else:
     reveal_type(abc) # N: Revealed type is "TypedDict('__main__.B', {'tag': Literal['B'], 'b': builtins.int})"
 
 [builtins fixtures/primitives.pyi]
+
+
+[case testNarrowingRuntimeCover]
+from typing import Dict, List, Union
+
+def unreachable(x: Union[str, List[str]]) -> None:
+    if isinstance(x, str):
+        reveal_type(x)  # N: Revealed type is "builtins.str"
+    elif isinstance(x, list):
+        reveal_type(x)  # N: Revealed type is "builtins.list[builtins.str]"
+    else:
+        reveal_type(x)  # N: Revealed type is "<nothing>"
+
+def all_parts_covered(x: Union[str, List[str], List[int], int]) -> None:
+    if isinstance(x, str):
+        reveal_type(x)  # N: Revealed type is "builtins.str"
+    elif isinstance(x, list):
+        reveal_type(x)  # N: Revealed type is "Union[builtins.list[builtins.str], builtins.list[builtins.int]]"
+    else:
+        reveal_type(x)  # N: Revealed type is "builtins.int"
+
+def two_type_vars(x: Union[str, Dict[str, int], Dict[bool, object], int]) -> None:
+    if isinstance(x, str):
+        reveal_type(x)  # N: Revealed type is "builtins.str"
+    elif isinstance(x, dict):
+        reveal_type(x)  # N: Revealed type is "Union[builtins.dict[builtins.str, builtins.int], builtins.dict[builtins.bool, builtins.object]]"
+    else:
+        reveal_type(x)  # N: Revealed type is "builtins.int"
+[builtins fixtures/dict.pyi]