diff --git a/mypy/checker.py b/mypy/checker.py
index 002f28d4db6c..3016a0eb237f 100644
--- a/mypy/checker.py
+++ b/mypy/checker.py
@@ -2415,6 +2415,29 @@ def check_assignment(self, lvalue: Lvalue, rvalue: Expression, infer_lvalue_type
                 self.infer_variable_type(inferred, lvalue, rvalue_type, rvalue)
             self.check_assignment_to_slots(lvalue)
 
+    def check_except_reachability(self, s: TryStmt) -> None:
+        """Perform except block reachability checks.
+
+        1. Check for duplicate exception clauses.
+        2. Check if super class has already been caught.
+        """
+        seen: List[Type] = []
+        for expr in s.types:
+            if expr and isinstance(expr, NameExpr) and isinstance(expr.node, TypeInfo):
+                with self.expr_checker.msg.filter_errors():
+                    typ = get_proper_type(self.check_except_handler_test(expr))
+                if isinstance(typ, AnyType) or isinstance(typ, UnionType):
+                    continue
+                if typ in seen:
+                    self.fail(message_registry.ALREADY_CAUGHT.format(format_type(typ)), expr)
+                    continue
+                seen_superclass = next((s for s in seen if is_subtype(typ, s)), None)
+                if seen_superclass is not None:
+                    self.fail(message_registry.SUPERCLASS_ALREADY_CAUGHT.format(
+                            format_type(seen_superclass), format_type(typ)), expr)
+                    continue
+                seen.append(typ)
+
     # (type, operator) tuples for augmented assignments supported with partial types
     partial_type_augmented_ops: Final = {
         ('builtins.list', '+'),
@@ -3777,6 +3800,9 @@ def visit_try_stmt(self, s: TryStmt) -> None:
             if not self.binder.is_unreachable():
                 self.accept(s.finally_body)
 
+        if self.should_report_unreachable_issues():
+            self.check_except_reachability(s)
+
     def visit_try_without_finally(self, s: TryStmt, try_frame: bool) -> None:
         """Type check a try statement, ignoring the finally block.
 
diff --git a/mypy/errorcodes.py b/mypy/errorcodes.py
index 85d6d9dd4159..53b598bcbd13 100644
--- a/mypy/errorcodes.py
+++ b/mypy/errorcodes.py
@@ -127,7 +127,7 @@ def __str__(self) -> str:
     'Reject returning value with "Any" type if return type is not "Any"',
     "General",
 )
-UNREACHABLE: Final = ErrorCode(
+UNREACHABLE: Final[ErrorCode] = ErrorCode(
     "unreachable", "Warn about unreachable statements or expressions", "General"
 )
 REDUNDANT_EXPR: Final = ErrorCode(
diff --git a/mypy/message_registry.py b/mypy/message_registry.py
index 0f14d706ccca..1f554224207b 100644
--- a/mypy/message_registry.py
+++ b/mypy/message_registry.py
@@ -257,3 +257,13 @@ def format(self, *args: object, **kwargs: object) -> "ErrorMessage":
 CLASS_PATTERN_UNKNOWN_KEYWORD: Final = 'Class "{}" has no attribute "{}"'
 MULTIPLE_ASSIGNMENTS_IN_PATTERN: Final = 'Multiple assignments to name "{}" in pattern'
 CANNOT_MODIFY_MATCH_ARGS: Final = 'Cannot assign to "__match_args__"'
+
+# Unreachable
+ALREADY_CAUGHT: Final = ErrorMessage(
+    "Except is unreachable, {} has already been caught",
+    code=codes.UNREACHABLE,
+)
+SUPERCLASS_ALREADY_CAUGHT: Final = ErrorMessage(
+    "Except is unreachable, superclass {} of {} has already been caught",
+    code=codes.UNREACHABLE,
+)
diff --git a/test-data/unit/check-unreachable-code.test b/test-data/unit/check-unreachable-code.test
index ef098c42901e..cdfd703ac0fa 100644
--- a/test-data/unit/check-unreachable-code.test
+++ b/test-data/unit/check-unreachable-code.test
@@ -841,6 +841,103 @@ def baz(x: int) -> int:
         return x
 [builtins fixtures/exception.pyi]
 
+[case testUnreachableFlagExcepts]
+# flags: --warn-unreachable
+from typing import Type, NoReturn
+
+def error() -> NoReturn: ...
+
+try:
+    error()
+except Exception:
+    pass
+except Exception as err:           # E: Except is unreachable, "Exception" has already been caught
+    pass
+except RuntimeError:               # E: Except is unreachable, superclass "Exception" of "RuntimeError" has already been caught
+    pass
+except (NotImplementedError, ):
+    pass
+except NotImplementedError:        # E: Except is unreachable, superclass "Exception" of "NotImplementedError" has already been caught
+    pass
+except NotImplementedError:        # E: Except is unreachable, superclass "Exception" of "NotImplementedError" has already been caught
+    pass
+[builtins fixtures/exception.pyi]
+
+[case testUnreachableFlagIgnoreVariablesInExcept]
+# flags: --warn-unreachable
+from typing import NoReturn, Union, Type, Tuple
+
+def error() -> NoReturn: ...
+class MyError(BaseException): ...
+
+ignore: Type[Exception]
+exclude: Tuple[Type[Exception], ...]
+omit: Union[Type[RuntimeError], Type[MyError]]
+
+try:
+    error()
+except ignore:
+    pass
+except exclude:
+    pass
+except omit:
+    pass
+except RuntimeError:
+    pass
+[builtins fixtures/exception.pyi]
+
+[case testUnreachableFlagExceptWithUnknownBaseClass]
+# flags: --warn-unreachable
+from typing import Any, NoReturn
+
+Parent: Any
+class MyError(Parent): ...
+def error() -> NoReturn: ...
+
+try:
+    error()
+except MyError:
+    pass
+except Exception:
+    pass
+except MyError:  # E: Except is unreachable, "MyError" has already been caught
+    pass
+[builtins fixtures/exception.pyi]
+
+[case testUnreachableFlagExceptWithError]
+# flags: --warn-unreachable
+from typing import NoReturn
+
+# The following class is not derived from 'BaseException'. Thus an error is raised
+# resulting in Any as type for the class in the exception expression. Such cases
+# must be ignored in the rest of the reachability analysis.
+class NotFromBaseException: ...
+
+def error() -> NoReturn: ...
+
+try:
+    error()
+except NotFromBaseException:   # E: Exception type must be derived from BaseException
+    pass
+except RuntimeError:
+    pass
+except NotImplementedError:    # E: Except is unreachable, superclass "RuntimeError" of "NotImplementedError" has already been caught
+    pass
+[builtins fixtures/exception.pyi]
+
+[case testUnreachableExceptWithoutUnreachableFlag]
+from typing import NoReturn
+
+def error() -> NoReturn: ...
+
+try:
+    error()
+except Exception:
+    pass
+except RuntimeError:
+    pass
+[builtins fixtures/exception.pyi]
+
 [case testUnreachableFlagIgnoresSemanticAnalysisUnreachable]
 # flags: --warn-unreachable --python-version 3.7 --platform win32 --always-false FOOBAR
 import sys