diff --git a/Cargo.toml b/Cargo.toml
index d582a0f..3d5fbb2 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -14,6 +14,12 @@ rusb = "0.8.0"
 rand = "0.6.1"
 
 [features]
+# Enable support for using this library across multiple threads.
+#
+# Made optional / opt-in for compatibility with AVR targets
+# which are single-core and do not have atomic operations.
+sync = []
+
 # Use a 256 byte buffer for control transfers instead of 128.
 control-buffer-256 = []
 
diff --git a/src/bus.rs b/src/bus.rs
index cd176d3..90fdc50 100644
--- a/src/bus.rs
+++ b/src/bus.rs
@@ -3,8 +3,83 @@ use crate::{Result, UsbDirection, UsbError};
 use core::cell::RefCell;
 use core::mem;
 use core::ptr;
+
+#[cfg(feature = "sync")]
 use core::sync::atomic::{AtomicPtr, Ordering};
 
+#[cfg(not(feature = "sync"))]
+use core::cell::Cell;
+
+pub(crate) struct BusPtr<B> {
+    #[cfg(feature = "sync")]
+    inner: AtomicPtr<B>,
+
+    #[cfg(not(feature = "sync"))]
+    inner: Cell<*mut B>,
+}
+
+impl<B> BusPtr<B> {
+    fn new() -> Self {
+        Self {
+            #[cfg(feature = "sync")]
+            inner: AtomicPtr::new(ptr::null_mut()),
+
+            #[cfg(not(feature = "sync"))]
+            inner: Cell::new(ptr::null_mut()),
+        }
+    }
+
+    fn set(&self, ptr: *mut B) {
+        #[cfg(feature = "sync")]
+        {
+            self.inner.store(ptr, Ordering::SeqCst);
+        }
+        #[cfg(not(feature = "sync"))]
+        {
+            self.inner.set(ptr);
+        }
+    }
+
+    pub(crate) fn get(&self) -> *mut B {
+        #[cfg(feature = "sync")]
+        {
+            self.inner.load(Ordering::SeqCst)
+        }
+
+        #[cfg(not(feature = "sync"))]
+        {
+            self.inner.get()
+        }
+    }
+}
+
+/// A trait with a `Sync` bound if the `sync` feature is enabled.
+///
+/// This is necessary because bounds can't be made conditional based on feature flags. Otherwise,
+/// the definition of `UsbBus` could be simpler, like:
+///
+/// ```compile_fail
+/// pub trait UsbBus: #[cfg(feature = "sync")] Sync + Sized {
+///     /* ... */
+/// }
+/// ```
+//
+// Another alternative would be to duplicate the `UsbBus` definition, one with the `Sync` bound and
+// one without, and conditionally select them based on the `sync` feature. But that's not feasible
+// to maintain by hand, because of how complex the `UsbBus` trait is. However, it may be possible
+// to do with a macro to automatically generate both definitions from one body.
+#[cfg(feature = "sync")]
+pub trait ConditionalSync: Sync {}
+
+#[cfg(feature = "sync")]
+impl<T: Sync> ConditionalSync for T {}
+
+#[cfg(not(feature = "sync"))]
+pub trait ConditionalSync {}
+
+#[cfg(not(feature = "sync"))]
+impl<T> ConditionalSync for T {}
+
 /// A trait for device-specific USB peripherals. Implement this to add support for a new hardware
 /// platform.
 ///
@@ -14,7 +89,7 @@ use core::sync::atomic::{AtomicPtr, Ordering};
 /// take place before [`enable`](UsbBus::enable) is called. After the bus is enabled, in practice
 /// most access won't mutate the object itself but only endpoint-specific registers and buffers, the
 /// access to which is mostly arbitrated by endpoint handles.
-pub trait UsbBus: Sync + Sized {
+pub trait UsbBus: ConditionalSync + Sized {
     /// Allocates an endpoint and specified endpoint parameters. This method is called by the device
     /// and class implementations to allocate endpoints, and can only be called before
     /// [`enable`](UsbBus::enable) is called.
@@ -148,7 +223,7 @@ struct AllocatorState {
 /// Helper type used for UsbBus resource allocation and initialization.
 pub struct UsbBusAllocator<B: UsbBus> {
     bus: RefCell<B>,
-    bus_ptr: AtomicPtr<B>,
+    bus_ptr: BusPtr<B>,
     state: RefCell<AllocatorState>,
 }
 
@@ -158,7 +233,7 @@ impl<B: UsbBus> UsbBusAllocator<B> {
     pub fn new(bus: B) -> UsbBusAllocator<B> {
         UsbBusAllocator {
             bus: RefCell::new(bus),
-            bus_ptr: AtomicPtr::new(ptr::null_mut()),
+            bus_ptr: BusPtr::new(),
             state: RefCell::new(AllocatorState {
                 next_interface_number: 0,
                 next_string_index: 4,
@@ -179,7 +254,7 @@ impl<B: UsbBus> UsbBusAllocator<B> {
         // in the RefCell.
         let mut bus_ref = self.bus.borrow_mut();
         let bus_ptr_v = &mut *bus_ref as *mut B;
-        self.bus_ptr.store(bus_ptr_v, Ordering::SeqCst);
+        self.bus_ptr.set(bus_ptr_v);
 
         // And then leave the RefCell borrowed permanently so that it cannot be borrowed mutably
         // anymore.
diff --git a/src/endpoint.rs b/src/endpoint.rs
index 520bccb..f004342 100644
--- a/src/endpoint.rs
+++ b/src/endpoint.rs
@@ -1,8 +1,7 @@
-use crate::bus::UsbBus;
+use crate::bus::{BusPtr, UsbBus};
 use crate::{Result, UsbDirection};
 use core::marker::PhantomData;
 use core::ptr;
-use core::sync::atomic::{AtomicPtr, Ordering};
 
 /// Trait for endpoint type markers.
 pub trait EndpointDirection {
@@ -49,7 +48,7 @@ pub enum EndpointType {
 /// Handle for a USB endpoint. The endpoint direction is constrained by the `D` type argument, which
 /// must be either `In` or `Out`.
 pub struct Endpoint<'a, B: UsbBus, D: EndpointDirection> {
-    bus_ptr: &'a AtomicPtr<B>,
+    bus_ptr: &'a BusPtr<B>,
     address: EndpointAddress,
     ep_type: EndpointType,
     max_packet_size: u16,
@@ -59,7 +58,7 @@ pub struct Endpoint<'a, B: UsbBus, D: EndpointDirection> {
 
 impl<B: UsbBus, D: EndpointDirection> Endpoint<'_, B, D> {
     pub(crate) fn new<'a>(
-        bus_ptr: &'a AtomicPtr<B>,
+        bus_ptr: &'a BusPtr<B>,
         address: EndpointAddress,
         ep_type: EndpointType,
         max_packet_size: u16,
@@ -76,7 +75,7 @@ impl<B: UsbBus, D: EndpointDirection> Endpoint<'_, B, D> {
     }
 
     fn bus(&self) -> &B {
-        let bus_ptr = self.bus_ptr.load(Ordering::SeqCst);
+        let bus_ptr = self.bus_ptr.get();
         if bus_ptr == ptr::null_mut() {
             panic!("UsbBus initialization not complete");
         }
diff --git a/src/lib.rs b/src/lib.rs
index d7744c9..706de98 100644
--- a/src/lib.rs
+++ b/src/lib.rs
@@ -192,6 +192,10 @@ pub mod class_prelude {
     pub use crate::UsbError;
 }
 
+#[cfg(all(feature = "sync", target_arch = "avr"))]
+compile_error!("`sync` feature is not supported on AVR targets.");
+
+#[cfg(feature = "sync")]
 fn _ensure_sync() {
     use crate::bus::{PollResult, UsbBus, UsbBusAllocator};
     use crate::class_prelude::*;