diff --git a/setup.py b/setup.py
index 10c92f73..6537c34f 100644
--- a/setup.py
+++ b/setup.py
@@ -31,14 +31,14 @@
 elif platform.system() == 'Darwin':
     extra_compile_args = FLAGS_CLANG + MACOS_FLAG
     extra_link_args = LFLAGS_CLANG + MACOS_FLAG
-elif platform.system() == 'FreeBSD':
+elif platform.system() in {'FreeBSD', 'OpenBSD'}:
     extra_compile_args = FLAGS_CLANG
     extra_link_args = LFLAGS_CLANG
 else:
     extra_compile_args = FLAGS_POSIX
     extra_link_args = LFLAGS_POSIX
 
-if platform.system() in {'Darwin', 'FreeBSD'}:
+if platform.system() in {'Darwin', 'FreeBSD', 'OpenBSD'}:
     os.environ.setdefault('CC', 'clang')
     os.environ.setdefault('CXX', 'clang++')
     orig_customize_compiler = distutils.sysconfig.customize_compiler
@@ -117,7 +117,7 @@ def customize_compiler(compiler):
         if get_build_version() < 14.0:
             msvc9compiler.get_build_version = lambda: 14.0
             msvc9compiler.VERSION = 14.0
-    elif platform.system() in ('Darwin', 'FreeBSD'):
+    elif platform.system() in {'Darwin', 'FreeBSD', 'OpenBSD'}:
         # Dirty workaround to avoid link error...
         # Python distutils doesn't provide any way
         # to configure different flags for each cc and c++.